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The physical properties of the test substance particularly the high water solubility (HLS, 1996) and low partition coefficient (HLS, 1996) would suggest that if the substance was bioavailable it would be unlikely to pass into the central nervous system. Acute toxicology particularly the acute oral study (HLS), revealed systemic effects of the test substance in the form of clinical signs. Clear evidence of oral absorption was seen in both the acute and repeated dose studies. There was some limited evidence of absorption via the dermal route. In a 28 -day oral (gavage) study (HLS, 1998), rats were dosed with 15, 50 or 150 mg/kg/day. The 28 Day Oral Toxicity Study revealed extensive effects in the liver providing evidence of distribution and metabolism. The changes were seen in liver weight and at both macroscopic and microscopic examination, the extent of the effects followed a dosage related trend.

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