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EC number: 240-241-0 | CAS number: 16088-62-3
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The result was obtained from a collection of reliable data which has been subject to peer-review and in which the original data sources are traceable.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
- Principles of method if other than guideline:
- According to Deneer et al. (1988, quoted in above report), a slow stirring method was employed to minimise the formation of emulsions and the test was conducted in triplicate at room temperature. Analysis was by gas-liquid chromatography (GLC).
- GLP compliance:
- no
- Type of method:
- other:
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- propylene oxide
- IUPAC Name:
- propylene oxide
- Reference substance name:
- Methyloxirane
- EC Number:
- 200-879-2
- EC Name:
- Methyloxirane
- Cas Number:
- 75-56-9
- IUPAC Name:
- 2-methyloxirane
- Details on test material:
- Test material was racemate from both R(+) and S(-) propylene oxide. This endpoint is not measured / determined with enantio-selective sensors.
Therefore the S(-) value is identical to the racemate endpoint.
Constituent 1
Constituent 2
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- >= 0.03 - <= 0.085
- Remarks on result:
- other: Test at room temperature
- Details on results:
- The experimental values obtained are in reasonably close agreement, (within the error margins of the experimental method).
Any other information on results incl. tables
A number of calculated log Kow values are quoted in IUCLID, ranging from -0.27 (Lipnick et al., 1987) to 0.35 (references from citation above).
Applicant's summary and conclusion
- Conclusions:
- A partition coefficient of 0.03 - 0.085 was obtained at room temperature for the propylene oxide in two reliable studies. A log KOW of 0.055 shall be
used for the exposure assessment.
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