Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: Weight of evidence
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The physico-chemical parameters as well as the bio-concentration factors can provide reliable indiactions on the toxico-kinetic behavior of a chemical & whether the chemical shall have a tendency to bio-accumulate.

Data source

Reference
Reference Type:
other: Weight of evidence
Title:
Toxicokinetics
Author:
Sustainability Support Services (Europe) AB
Year:
2012
Bibliographic source:
Based on the weight of evidence of various phys chem and bioaccumulative parameters in the dossier

Materials and methods

Objective of study:
toxicokinetics
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Based on the weight of evidence of various phys chem and bioaccumulative parameters in the dossier
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-Naphthalenol, 1-[[4-(phenylazo)phenyl]azo]-, ar',ar''-Me derivs.
EC Number:
274-972-1
EC Name:
2-Naphthalenol, 1-[[4-(phenylazo)phenyl]azo]-, ar',ar''-Me derivs.
Cas Number:
70879-65-1
Molecular formula:
C23H17N4O
IUPAC Name:
2-Naphthalenol, 1-[[4-(phenylazo)phenyl]azo]-, ar',ar''-Me derivs
Details on test material:
Not applicable

Test animals

Species:
other: unspecified
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
Not applicable

Administration / exposure

Route of administration:
other: estimation
Vehicle:
unchanged (no vehicle)
Details on exposure:
Not applicable
Duration and frequency of treatment / exposure:
Not applicable
Doses / concentrations
Remarks:
Doses / Concentrations:
Not applicable
No. of animals per sex per dose / concentration:
Not applicable
Positive control reference chemical:
Not applicable
Details on study design:
Not applicable
Details on dosing and sampling:
Not applicable

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:
Since vapour pressure of 2-Naphthalenol, 1-[[4-(phenylazo)phenyl]azo]-, ar',ar''-Me derivs is very low (0.000000034 Pa) so there is no possibility of absorption throuth inhalation route. There is no data available on the dermal and oral absorption of the chemical.

Details on distribution in tissues:
The water solubility of 2-Naphthalenol, 1-[[4-(phenylazo)phenyl]azo]-, ar',ar''-Me derivs is less compared to its solubility in organic solvent. Hence any absorbed 2-Naphthalenol, 1-[[4-(phenylazo)phenyl]azo]-, ar',ar''-Me derivs is likely to be distributed more by the lipids within the living system than through blood.


Details on excretion:
The predicted bio-concentration factor (BCF) value for 2-Naphthalenol, 1-[[4-(phenylazo)phenyl]azo]-, ar',ar''-Me derivs is 10. THis value is much less than the threshold value of 2000 (suggestive of bio-accumulation). Thus, if a chemical is unlikely to bio-accumulate inside the living system, it shall be excreted out, either through the urine or the feaces.

Metabolite characterisation studies

Metabolites identified:
no
Details on metabolites:
Not applicable

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): other: Low bio-accumulation potential deduced on the basis of physico-chemical properties and bio-concentration factor
Based upon the physico-chemical properties and BCF of 2-Naphthalenol, 1-[[4-(phenylazo)phenyl]azo]-, ar',ar''-Me derivs, it has been deduced that the chemical has potentially low bio-accumulative property and hence shall be eliminated from the body system through urine or feaces.
Executive summary:
Based upon the physico-chemical properties and BCF of 2-Naphthalenol, 1-[[4-(phenylazo)phenyl]azo]-, ar',ar''-Me derivs, it has been deduced that the chemical has potentially low bio-accumulative property and hence shall be eliminated from the body system through urine or feaces.