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EC number: 401-540-3 | CAS number: -
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Reliability is assumed to be 1 as data are taken from NONS file
Data source
Reference
- Reference Type:
- other: Body reponsible for the test
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 401-540-3
- EC Name:
- -
- Cas Number:
- 84632-65-5
- Molecular formula:
- C18H10Cl2N2O2
- IUPAC Name:
- 3,6-bis(4-chlorophenyl)-1H,2H,4H,5H-pyrrolo[3,4-c]pyrrole-1,4-dione
- Details on test material:
- - Name of test material (as cited in study report): none specified, but the substance was Pigment Red 254 (EC 401-540-3; CAS 84632-65-5)
- Substance type: pigment
- Physical state: solid
- Analytical purity: -
- Other: -
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: 10% (w/w) Sipernat 50s
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- 2.25 mg/L air
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.25 mg/L air
- Exp. duration:
- 4 h
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 2.25 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- Male: 2.25 mg/L; Number of animals: 5; Number of deaths: 0
Female: 2.25 mg/L; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: Inspecific symptoms, reversible after 5 to 9 days.
- Gross pathology:
- During the autopsy no specific damages were found.
The histopathology did not reveal any substance-related effects.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a GLP-study according to OECD test guideline 403, PR 254 was not toxic at a concentration of 2.25 mg/l air via the inhalation route. Therefore, it is considered to be not acutely toxic via the inhalation route.
- Executive summary:
In a GLP-study according to OECD test guideline 403, PR 254 was not toxic at a concentration of 2.25 mg/l air via the inhalation route. Therefore, it is considered to be not acutely toxic via the inhalation route.
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