Registration Dossier

Toxicological information

Additional toxicological data

Currently viewing:

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1995
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1995
Report Date:
1995

Materials and methods

Type of study / information:
Review of toxicology
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Applicant's summary and conclusion

Conclusions:
Piperonyl butoxide has a low order of acute and chronic toxicity, is not genotoxic, teratogenic, toxic to the reproductive system or oncogenic in three mouse and two rat oncogenicity studies. The liver is the principal target organ and the main toxicological findings are a consequence of hepatotoxicity at very high doses.