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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1972
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
review article or handbook
Title:
Effects of Piperonyl butoxide on drug metabolism in rodents and man
Author:
Conney, A.H., Chang, R., Levin, W.M., Garbut, A., Munro-Faure, A.D., Peck, A.W., Bye, A.
Year:
1972
Bibliographic source:
Arch. Env. Health 24, 97-106.

Materials and methods

Type of study / information:
Type of experience: Human
Endpoint addressed:
basic toxicokinetics
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Results:
No adverse effects were reported.The mean half-life of antipyrine was not influenced. There was no evidence that an oral dose of 50 mg Piperonyl  Butoxide in humans has any effect on the metabolism of antipyrine in  humans.

Applicant's summary and conclusion

Conclusions:
No adverse effects were reported.The mean half-life of antipyrine was not influenced. There was no evidence that an oral dose of 50 mg Piperonyl  Butoxide in humans has any effect on the metabolism of antipyrine in  humans.