Registration Dossier

Ecotoxicological information

Toxicity to birds

Currently viewing:

Administrative data

Endpoint:
short-term toxicity to birds: acute oral toxicity test
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1991
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991
Report Date:
1991

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EPA OPP 71-1 (Avian Acute Oral Toxicity Test)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Vehicle:
yes

Test organisms

Test organisms (species):
Colinus virginianus

Study design

Total exposure duration (if not bolus):
14 d
No. of animals per sex per dose and/or stage:
60
Each dosage group was assigned two pens. One pen contained five males and the other five females
[800 cm2 / bird]

Results and discussion

Effect levelsopen allclose all
Duration (if not bolus):
14 d
Dose descriptor:
NOEC
Effect level:
486 mg/kg bw
Conc. / dose based on:
not specified
Basis for effect:
not specified
Duration (if not bolus):
14 d
Dose descriptor:
LC50
Effect level:
> 2 250 mg/kg bw
Conc. / dose based on:
not specified
Basis for effect:
not specified

Applicant's summary and conclusion

Conclusions:
The acute oral LD50 for northern bobwhite quail exposed to PBO as a single oral dose was determined to be greater than 2250 mg a.i./kg bw. The NOEL was 486 mg a.i./kg bw, based on the loss in body weight among females at 810 mg a.i./kg during the first three days only.