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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2006
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
4.8
Temp.:
20 °C
pH:
6.5

The test item can be considered as not ionisable because the water solubility showed no pH dependency. Thus a pH dependence of the Pow of substance test was not expected and the partition coefficient was determined only at pH 6.5.

Conclusions:
The determination of the octanol/water partition coefficient of substance test was performed according to EC method A.8, and OECD guideline 117, HPLC Method.
The log Pow was found to be 4.80 (pH = 6.5) at 20°C.

Description of key information

The determination of the octanol/water partition coefficient of substance test was performed according to EC method A.8, and OECD guideline 117, HPLC Method.

Log Pow at 20 °C and pH of 6.5 = 4.8 (OECD Guideline 117 (Partition Coefficient ((n-octanol / water); HPLC Method); EU Method A.8 (Partition Coefficient))

Key value for chemical safety assessment

Log Kow (Log Pow):
4.8
at the temperature of:
20 °C

Additional information

The test item can be considered as not ionisable because the water solubility showed no pH dependency. Thus a pH dependence of the Pow of substance test was not expected and the partition coefficient was determined only at pH 6.5.