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EC number: 203-929-1 | CAS number: 112-03-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 13, 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: the screening test is similar to the preliminary test in OECD guideline for the testing of chemicals, No. 105, Water Solubility
- Version / remarks:
- see 'Principles of method if other than guideline'
- Principles of method if other than guideline:
- The solubility of the test substance is investigated in a combined screening test (which is similar to OECD TG 105) followed by LCMS analysis of solutions obtained in the screening test.
- GLP compliance:
- not specified
- Key result
- Medium:
- n-octanol
- Solubility:
- 200 g/L
- Temp.:
- 23 °C
- Remarks on result:
- other: analysed using LCMS
- Conclusions:
- Under the study conditions, the octanol solubility of the test substance was determined to be 200 g/L at 23°C.
- Executive summary:
A study was conducted to determine the solubility of the test substance, C18 TMAC (Purity: 99.2%) in organic solvents according to a method that is similar to OECD Guideline 105. The octanol solubility for the test substance was evaluated with a combined screening test and a LCMS analysis. The measurement was performed at room temperature, approximately 23°C. Under the study conditions, the octanol solubility of the test substance was determined to be 200000 mg/L at 23 °C (Farnback, 2012).
Reference
Screening test results
Test |
Approximate concentration |
Result |
F1 |
2000 g/l |
Powder, no solution |
F2 |
1000 g/l |
Powder, no solution |
F3 |
500 g/l |
Highly viscous gel with undissolved material. Almost no solution |
F4 |
250 g/l |
Clear solution |
LCMS results
Test |
Determined concentration |
F3 |
200 g/l |
F4 |
210 g/l |
Average |
200 g/l |
The results for F3 and F4 are similar and indicate that F4 is close to saturation, even if no undissolved material was present.
Description of key information
The solubility in organic solvents of the test substance was determined using LCMS analysis according to a method that is similar to OECD Guideline 105 (Farnback, 2012).
Key value for chemical safety assessment
- Solubility in organic solvents at 20°C:
- 200 g/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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