Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-089-2 | CAS number: 629-40-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Bacterial reverse mutation assays
The gene mutation potential of the test substance (99.18% pure) was evaluated in a bacterial reverse mutation assay (Ames test). The test was performed according to the OECD test guidelines 471 (adopted 1983) under GLP conditions with the Salmonella Typhimurium strains TA 98, TA 100, TA 1535 and TA 1537. The concentration of the test substance ranged from 20 to the limit concentration of 5000 µg/plate in both experiments (standard plate test and preincubation test) and DMSO was used as solvent. Cytotoxicity was observed in the standard plate test at 5000 µg/plate in TA1537 and TA 100 without metabolic activation and at 2500 µg/plate in TA100 with metabolic activation. No precipitation was observed in any strain. The induced number of revertants per plate was comparable to the vehicle control conditions for all strains tested, with and without metabolic activation. Thus, the test substance was not mutagenic in bacteria under the test conditions chosen. The actual guideline requires an additional strain (E. Coli or TA 102) and an additional positive control beside 2-aminoanthracene with metabolic activation. Nevertheless, the study is considered suitable for assessment of the gene mutation potential of the test substance (BASF AG, 1992).
Short description of key information:
BASF AG 40M0319/914182, 1992, reliability score = 2; result: negative
Endpoint Conclusion:
Justification for classification or non-classification
Dangerous substance Directive (67/548/EEC)
The available experimental test data are considered reliable and suitable, but are not sufficient for the purpose of classification.
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable, but not sufficient for the purpose of classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
