Suberonitrile

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with restrictions (limited documentation, 4 h exposure, occlusive treatment, limit test with only 1884 mg/kg bw and 5 animals)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1963

Report date:

1963

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

yes

Remarks:

(limited documentation, 4 h exposure, occlusive exposure, limit dose 1884 mg/kg bw instead of 2000, only 5 animals tested)

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Suberonitrile

EC Number:

211-089-2

EC Name:

Suberonitrile

Cas Number:

629-40-3

Molecular formula:

C8H12N2

IUPAC Name:

octanedinitrile

Details on test material:

- Name of test substance (as cited in study report): Korksaeuredinitril
- Analytical purity: no data
- Physical state: liquid
- Density: 0.942 g/mL

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 131 g (mean)

No additional information reported.

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Area of exposure: 30 cm²
- Type of wrap if used: no wrap; animals were placed in a bath tub filled with the test substance

REMOVAL OF TEST SUBSTANCE
- Washing (if done): Lutrol (conc.)
- Time after start of exposure: 4 h

TEST MATERIAL
- Amount(s) applied: 2 mL of the pure test substance

Duration of exposure:

4 h

Doses:

2000 µg/kg bw (corresponding to approx. 1884 mg/kg bw; calculated assuming test substance density = 0.942 g/mL)

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: no data
- Frequency of weighing: before application and at the end of the study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD0

Effect level:

1 884 mg/kg bw

Based on:

test mat.

Remarks on result:

other: calculated assuming test substance densitiy = 0.942 g/mL

Mortality:

0/5 animals died

Clinical signs:

other: No clinical signs of toxicity were observed.

Gross pathology:

No abnormalities were observed.

Other findings:

No symptoms of local irritation were observed.