Suberonitrile

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with restrictions (limited documentation, no analytic test concentration)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1963

Report date:

1963

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

(adopted 1981)

Deviations:

yes

Remarks:

(limited documentation, no analytical concentration, 8 h exposure)

GLP compliance:

no

Test type:

other: Inhalation Hazard Test

Test material

Test material information

Constituent 1

Reference substance name:

Suberonitrile

EC Number:

211-089-2

EC Name:

Suberonitrile

Cas Number:

629-40-3

Molecular formula:

C8H12N2

IUPAC Name:

octanedinitrile

Details on test material:

- Name of test substance (as cited in study report): Korksaeuredinitril
- Analytical purity: no data
- Sample No.: C 520/326
- Physical state: liquid
- Density: 0.942 g/mL

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Mean weight at study initiation: 166 g (males and females)

No additional details reported.

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: exsiccator and wash bottle
- Source and rate of air: 200 L air per hour
- System of generating vapour: for saturation, air was passed through a circa 5 cm high layer of the compound
- Temperature in air chamber: 20 °C

TEST ATMOSPHERE
- Samples taken from breathing zone: no

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

1.24 mg/L (first experiment) and 0.018 mg/L (second experiment)
(Based on the weight differences of test substance (1.99 g and 0.03 g) before and after exposure divided by the air volume of 200 L and the exposure time of 8 h)

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations: no data
- Frequency of weighing: before exposure and before sacrifice
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

1.24 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

8 h

Mortality:

0/12 animals died

Clinical signs:

other: No signs of clinical toxicity were observed.

Body weight:

Mean body weights:
- Day 0: 171 g and 160 g
- Day 7: 183 g and 187 g
(first and second experiment; each group consists of 3 males and 3 females)

Gross pathology:

No abnormalities detected.