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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
genetic toxicity in vitro
Remarks:
Type of genotoxicity: other: Cytotoxicity
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Authoritative data base
Title:
Danish QSAR study for CAS No.: 5246-57-1
Author:
Danish EPA Model
Year:
2012
Bibliographic source:
QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Modelling database
Principles of method if other than guideline:
Data is from Multicase model
GLP compliance:
no
Type of assay:
other: Cell transform. (SHE): Syrian hamster embryo cell transformation assay

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 2-[(3-aminophenyl)sulphonyl]ethanol
- Substance type: Organic
- Physical state: Solid

Method

Species / strain
Species / strain:
other: Syrian hamster embryo cell
Additional strain characteristics:
not specified
Metabolic activation:
not specified
Metabolic activation system:
none

Results and discussion

Test results
Species / strain:
other: Syrian hamster embryo cell
Metabolic activation:
not specified
Genotoxicity:
not specified
Cytotoxicity:
no
Vehicle controls valid:
not specified
Negative controls valid:
not specified
Positive controls valid:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative

Cell transform. (SHE): Syrian hamster embryo cell transformation assay with 2-[(3-aminophenyl)sulphonyl]ethanol resulted as Negative
Executive summary:

Cell transform. (SHE): Syrian hamster embryo cell transformation assay with 2-[(3-aminophenyl)sulphonyl]ethanol resulted as Negative.