Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

The substance (NBDI, an aliphatic diisocyanate) reacts with water. From this reaction, the diamine NBDA is formed and CO2.

Available data about the conversion rate of NBDI to NBDA in water: after 3 hours a conversion rate of 60-85% was shown (depending on the initial concentration). It has been shown, in the environmental studies, that NBDA is hydrolytically stable and that the parent compound (NBDI) is not. Based on this information (e.g. half-life NBDI less than 12 hours; NBDI is not present in the environment), it is considered justified to conclude that the CSA for the environment needs to based on NBDA. The key values for the CSA are therefore the key values applicable for NBDA:

-96h-LC50 for freshwater fish: >82 mg NBDA/L

-48h-EC50 for freshwater invertebrates: 42 mg NBDA/L

-72h-ErC50 for freshwater algae: 19.1 mg NBDA/L

-3h-EC50 for STP micro-organisms: 14.7 mg NBDA/L