Registration Dossier
Registration Dossier
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EC number: 210-539-5 | CAS number: 617-94-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary references
Data source
Materials and methods
Results and discussion
Any other information on results incl. tables
ADME |
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The substance (0.5 g/kg, administered orally to rabbits) was excreted almost entirely (85%) in the urine as a conjugated glucuronide (Robinson, Smith & Williams, 1955).
In vivo studies in animals. In a study of the metabolism of cumene in rabbits, it was reported that cumene is metabolized to the substance , which is subsequently excreted in the urine as a conjugate of glucuronic acid
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Robinson. D.. Smith. J. N. & Williams. R. T. (1955). Studies in detoxication. 60. The metabolism of alkylbenzenes, isopropylbenzene (cumene) and derivatives of hydratropic acid.Biochem. J.59, 153. Cited in:Food and Chemical Toxicology. Vol. 20, Pg. 675, 1982
Robinson. D.. Smith. J. N. & Williams. R. T. (1955). Studies in detoxication. 60. The metabolism of alkylbenzenes, isopropylbenzene (cumene) and derivatives of hydratropic acid.Biochem. J.59, 153. Cited in:Scognamiglio J,Jones L,Letizia CS,Api AM.Fragrance material review on 2-phenyl-2-propanol.Food Chem Toxicol.2012 Sep;50 Suppl 2:S130-3. |
In a study comparing rates of metabolism of a series of alkyl benzenes by rabbit liver, locust fat body and fly abdomen homogenates, it was reported that rabbit liver metabolizes 2-phenyl-2-propanol at the rate of 0.17– 0.35 lmol/min/g of whole tissue |
Chakraborty, J., Smith, J.N., 1967. Enzymic oxidation of some alkylbenzenes in insects and vertebrates. Biochem. J. 102, 498–503 Cited in:Scognamiglio J,Jones L,Letizia CS,Api AM.Fragrance material review on 2-phenyl-2-propanol.Food Chem Toxicol.2012 Sep;50 Suppl 2:S130-3. |
Applicant's summary and conclusion
- Conclusions:
- See Any Other Information on Results section.
- Executive summary:
See Any Other Information on Results section.
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