Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 618-126-5 | CAS number: 88196-70-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study conducted according to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 62409-13-6
- Cas Number:
- 62409-13-6
- IUPAC Name:
- 62409-13-6
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:(WI)BR
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 300 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- 2000 mg/kg b.w.: all animals died on the day of the administration
- Gross pathology:
- An abnormal finding, namely a systolic heart arrest, was present only in deceased animals (2000 mg/kg bw).
All other animals were normal at the necropsy 14 d. - Other findings:
- All animals were affected after administation.
The findings, with an onset shortly after the administration and lasting until death or to a
maximum of 6 h were:
Central nervous effects: clonic convulsions. Signs of reduced well-being. This term encompasses unspecific alterations, like sedation,
apathy, piloerection, hunched posture or closed eyes, in single or multiple occurrence.
Applicant's summary and conclusion
- Conclusions:
- According to the GHS (Globally Harmonised System) the test substance "rac-1-(3-Methoxyphenyl)ethylamine" should be classified in the hazard category 4 (LD50 value in the range of 300 - 2000 mg per kg body weight).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
