Registration Dossier
Registration Dossier
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EC number: 273-732-3 | CAS number: 69012-32-4 By-product of smelting of phosphate rock, silica and coke in manufacture of phosphorus.
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on developmental toxicity
Description of key information
Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test (OECD 422)
- Developmental NOAEL: 1000 mg/kg bw/day
Additional information
The key study was a 28-day Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test performed according to OECD 422 under GLP conditions, in which a developmental (and reproduction) NOAEL of 1000 mg/kg bw/day was established based on the absence of adverse effects up to the highest dose.
Justification for classification or non-classification
When considering the developmental NOAEL of 1000 mg/kg bw/day and the criteria outlined in Annex I of 1272/2008/EC and Annex VI of 67/548/EEC, P-slag does not need to be classified for reproduction toxicity.
Additional information
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