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Registration Dossier
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EC number: 273-732-3 | CAS number: 69012-32-4 By-product of smelting of phosphate rock, silica and coke in manufacture of phosphorus.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
There is very little information available to base the toxicokinetic assessment of P-slag on. No key studies are available, but a supporting study is included in the dossier concerning the biodurability of wollastonite. The available toxicity studies provide no or little information. Only a few physicochemical properties are available that can be used.
Physical/chemical properties
P-slag is a multi constituent substance containing inorganic mineral silicates with a fibrous particle structure. Therefore a Log-P and vapour pressure is not applicable. The water solubility is very low. A dissolution/transformation protocol study learned that after 7 days < 1% of some elements (Si, F) were solved. If the cristalline structure of P-slag would solve in water, the elements would be present as ions in solution.
Absorption
Based on the very low water solubility it is expected that absorption via oral and dermal exposure will be very limited.
Exposure through inhalation of P-slag particles is the main route of possible exposure. However, respiratory absorption will also be very limited. The deposition, clearance and uptake of inorganic particles in the lungs will depend on the particle size, location of deposition, mucus production and macrophage activity. The average percentage of particles with a diameter of < 63 μm in the test substance is 1,3 (m/m) %. So the particles can be inhaled, and a small portion will reach the thoracic region.
Distribution, metabolism and excretion
In a supporting study (Bellman, 1994) the bio durability of wollastonite, a main constituent of P-slag, has been studied. This study revealed that the elimination kinetics of wollastonite fibers from the lung were relatively fast, with half-times of 15 to 21 days. For the thoracic fraction of wollastonite, the elimination from the lung was as fast as for the respirable particulate fraction. This suggests that mechanical clearance mediated by macrophages could be only of minor importance for wollastonite, for which dissolution of fibers must be the important clearance process. This elimination rate must be considered as a rough indication of the elimination of P-slag since this rate may differ substantially between different shapes of wollastonite and wollastonite is only a constituent of P-slag.
There is no further information about the systemic distribution, metabolism, excretion, bioavailability and accumulation of P-slag.
Conclusion:
After respiratory exposure, the amount of absorption of P-slag will be limited, and elimination of from the lung is relatively fast. It is expected that P-slag is not absorbed via the oral and dermal route.
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