Potassium hydroxyoctaoxodizincatedichromate(1-)

Developmental toxicity / teratogenicity

Administrative data

Endpoint:

developmental toxicity

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Summary of available, relevant studies on chromates. All are acceptable study reports which meet basic scinetific principles.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Chromium induced teratogenicity in female rat.

Author:

Kanojia, R. K., M. Junaid, et al.

Year:

1996

Bibliographic source:

Toxicol Lett.89(3): 207-13.

Reference 2

Reference Type:

publication

Title:

Embryo and fetotoxicity of hexavalent chromium: a long-term study.

Author:

Kanojia, R. K., M. Junaid, et al.

Year:

1998

Bibliographic source:

Toxicol Lett.95(3): 165-72.

Reference 3

Reference Type:

publication

Title:

Short-term exposure of female rats to industrial metal salts: Effect on implantation and pregnancy.

Author:

Bataineh, H. N., Z. M. Bataineh, et al.

Year:

2007

Bibliographic source:

Reprod Med Biol.6: 179-183.

Reference 4

Reference Type:

publication

Title:

Sexual maturation and fertility of male and female mice exposed prenatally and postnatally to trivalent and hexavalent chromium compounds.

Author:

Al-Hamood, M. H., A. Elbetieha, et al.

Year:

1998

Bibliographic source:

Reprod Fertil Dev.10(2): 179-83.

Reference 5

Reference Type:

publication

Title:

Teratogenicity of hexavalent chromium in rats and the beneficial role of ginseng.

Author:

Elsaieed, E. M. and S. A. Nada

Year:

2002

Bibliographic source:

Bull Environ Contam Toxicol.68(3): 361-8.

Materials and methods

Principles of method if other than guideline:

List of other studies on developmental toxicity of soluble chromates after oral exposure.

Results and discussion

Results (fetuses)

Fetal abnormalities

Abnormalities:

not specified

Overall developmental toxicity

Developmental effects observed:

not specified

Any other information on results incl. tables

 

Table 1
Developmental effects of soluble chromates
(*= key study)
strain	chromate	study design	results	reference
female Swiss albino rats	potassium dichromate	250-750 ppm in drinking water for 20 days prior to mating	decreased number of live foetuses; reduced foetal ossification; increased numbers of subdermal hemorrhagic thoracic abdominal patches, kinky tails, short tails; no gross visceral abnormalities observed	(Kanojia, Junaid et al. 1996)
female Duckrey rats	potassium dichromate	250-750 ppm in drinking water for 3 months prior to mating	reduced foetal weight; reduced ossification and crown-rump lengths; no gross visceral abnormalities	(Kanojia, Junaid et al. 1998)
mated female rats	potassium dichromate	25 mg/kg/day by gavage on gestational days 1-6	decreased number of implantations and live foetuses	(Bataineh, Bataineh et al. 2007)
pregnant female BALB/c mice	potassium dichromate	66 mg Cr(VI)/kg/day in drinking water on gestation day 12 through lactation day 20	decreases in numbers of pregnant animals, implantations and viable foetuses when female offspring were mated with unexposed males; no developmental effects in male offspring	(Al-Hamood, Elbetieha et al. 1998)
pregnant rats	potassium dichromate	50 ppm drinking water during days 6-15 of gestation	inbreased number of dead foetuses; decreased foetal weight; increased visceral (renal pelvis dilatation) abnormalities and incomplete ossification of skull bone	(Elsaieed and Nada 2002)