Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

Currently viewing:

Administrative data

acute toxicity: other routes
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Read-across from a sparingly water soluble chromate and from a highly water soluble chromate. Not a guideline or GLP study.
Reason / purpose for cross-reference:
reference to same study

Data source

Reference Type:
Toxicokinetics of hexavalent chromium in the rat after intratracheal administration of chromates of different solubilities.
Bragt, P. C. and E. A. van Dura
Bibliographic source:
Ann Occup Hyg.27(3): 315-22.

Materials and methods

Principles of method if other than guideline:
kinetics in the rat after a single intratracheal dose of a substance
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
sodium chromate, zinc chromate, lead chromate
sodium chromate, zinc chromate, lead chromate

Test animals

Details on test animals or test system and environmental conditions:
- Weight at study initiation: 165-200 g
- Housing: individually in stainless steel metabolic cages
- Diet (e.g. ad libitum): standard pellet diet (Hope Farms, Woerden, the Netherlands)
- Water (e.g. ad libitum): ad libidum

Administration / exposure

Route of administration:
other: intratracheal
Details on exposure:
The animals were anaesthesised during injection.
20 ul solution or suspension of either sodium chromate (69 ug Cr), zinc chromate (66 ug Cr) or lead chromate (38 ug Cr) in saline containing 0.4-6.0 uCi 51Cr;

Results and discussion

Any other information on results incl. tables

Zinc chromate caused macroscopically visible haemorrhages and exudation of the lungs within 24 h after its administration, resulting in irregular and halting breathing. These symptoms disappeared on day 6.

Applicant's summary and conclusion

Executive summary:

Bragt and van Dura (1983) studied the kinetics of chromium in the rat after a single intratracheal dose of sodium, zinc or lead51Cr-chromate. The rats received a 20 μl solution or suspension of either sodium chromate (69 μg Cr), zinc chromate (66 μg Cr) or lead chromate (38 μg Cr). Intratracheal instillation of sparingly water-soluble zinc chromate produced irregular breathing and lung haemorrhage and oedema at 24 hours in male Wistar rats.