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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Acceptable study report. Results presented in sufficient detail, but methods were only briefly described.

Data source

Reference
Reference Type:
publication
Title:
Accumulation of toxic metals in male reproductive organs.
Author:
Danielsson, B. R. G., L. Dencker, et al.
Year:
1984
Bibliographic source:
Arch Toxicol.Suppl. 7: 177-180.

Materials and methods

Objective of study:
distribution
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The accumulation of chromium(VI) in male reproductive organs of mice was presented.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Sodium dichromate Na2[51]Cr2O7 obtained from the Radiochemical Centre, Amersham, England.
No details presented.
Radiolabelling:
yes

Test animals

Species:
mouse
Strain:
not specified
Sex:
male
Details on test animals and environmental conditions:
No details presented.

Administration / exposure

Route of administration:
intravenous
Vehicle:
not specified
Duration and frequency of treatment / exposure:
Single injection.
Doses / concentrations
Remarks:
Doses / Concentrations:
No data
No. of animals per sex per dose:
No data
Control animals:
no
Details on study design:
- Dose selection rationale: no data
- Rationale for animal assignment (if not random): no data
Details on dosing and sampling:
72 h afters i.v. injection the animals were killed ad tissues fixed. Cr(VI) in formalin-fixed testicular tissue was studied by microautoradiography
Statistics:
No data

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on distribution in tissues:
Microautoradiographic studies showed a relatively large uptake of Cr in the intestinal tissues. The uptake was probably concentrated to Leydig cells. No radioactivity was detected in blood vessels or in the spermatogenetic epithelium.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no data
After an intravenous injection of radiolabelled sodium dichromate the label was taken up in the interstitial tissues. No radioactivity could be detected in blood vessels or the spermatogenic epithelium. The authors speculated that the Leydig cells could be the primary target of chromium in the testis.
Executive summary:

A microautoradiographic study of the testis (no methodological details were provided) showed that after an intravenous injection of radiolabelled sodium dichromate the label was taken up in the interstitial tissues (Danielsson, Dencker et al. 1984). No radioactivity could be detected in blood vessels or the spermatogenic epithelium. The authors speculated that the Leydig cells could be the primary target of chromium in the testis.