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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data of read across substances
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two hydrolysis studies as-
WoE 2. and WoE 3.
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
not specified
Estimation method (if used):
Structure estimation method
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
pH:
7
DT50:
3.3 yr
Type:
second order
Remarks on result:
other: WoE 2: Hydrolysis rate constant is 0.063 L/mol-sec.
pH:
8
DT50:
121 d
Type:
second order
Remarks on result:
other: WoE 2: Hydrolysis rate constant is 0.063 L/mol-sec.
pH:
7
DT50:
2.1 yr
Type:
second order
Remarks on result:
other: WoE 3: Hydrolysis rate constant is 0.10 L/mol-sec
pH:
8
DT50:
78 d
Type:
second order
Remarks on result:
other: WoE 3: Hydrolysis rate constant is 0.10 L/mol-sec
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of the experimental studies of the read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 2.1 to 3.3 yrs at pH 7.0 and 78 to 121 days at pH 8.0 with a corresponding hydrolysis rate constant of 0.063L/mol-sec & 0.10L/mol-sec, respectively. Thus, based on this half-life value, test chemical can be considered to be hydrolytically stable.
Executive summary:

Data available for its read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:

The half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test substance was determined to be 0.063L/mol-sec with a corresponding half-lives of 3.3 yrs and 121 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that test chemical is not hydrolysable.

In another study, the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test substance was determined to be 0.10L/mol-sec with a corresponding half-lives of 2.1 yrs and 78 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that test chemical is not hydrolysable.

On the basis of the experimental studies of the read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 2.1 to 3.3 yrs at pH 7.0 and 78 to 121 days at pH 8.0 with a corresponding hydrolysis rate constant of 0.063L/mol-sec & 0.10L/mol-sec, respectively. Thus, based on this half-life value, test chemical can be considered to be hydrolytically stable.

Description of key information

On the basis of the experimental studies of the read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 2.1 to 3.3 yrs at pH 7.0 and 78 to 121 days at pH 8.0 with a corresponding hydrolysis rate constant of 0.063L/mol-sec & 0.10L/mol-sec, respectively. Thus, based on this half-life value, test chemical can be considered to be hydrolytically stable.

Key value for chemical safety assessment

Additional information

Data available for its read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:

 

The half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test substance was determined to be 0.063L/mol-sec with a corresponding half-lives of 3.3 yrs and 121 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that test chemical is not hydrolysable.

 

In another study, the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test substance was determined to be 0.10L/mol-sec with a corresponding half-lives of 2.1 yrs and 78 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that test chemical is not hydrolysable.

 

On the basis of the experimental studies of the read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 2.1 to 3.3 yrs at pH 7.0 and 78 to 121 days at pH 8.0 with a corresponding hydrolysis rate constant of 0.063L/mol-sec & 0.10L/mol-sec, respectively. Thus, based on this half-life value, test chemical can be considered to be hydrolytically stable.

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