Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-904-0 | CAS number: 25371-54-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1971-12-02 to 1972-01-05
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP/non-guideline study (this study was conducted in the United States prior to issue of the OPPTS harmonised Test Guidelines).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- no guideline available
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Undiluted dimethyl octadecyl phosphonate (DMOP) was applied to the closely clipped, intact skin of New Zealand white male and female rabbits.at 5 dose levels ranging from 1260 mg/kg to 7940 mg/kg (one animal per dose rate (male animals were dosed at 1260, 3160 and 7940 mg/kg; female animals were dosed at 2000 and 5010mg/kg). The treated areas were covered with occlusive dressings and the animals were observed for clinical signs for a period of 14 days (or until death). Necropsy of all animals was performed.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyl octadecylphosphonate
- EC Number:
- 246-904-0
- EC Name:
- Dimethyl octadecylphosphonate
- Cas Number:
- 25371-54-4
- Molecular formula:
- C20H43O3P
- IUPAC Name:
- dimethyl octadecylphosphonate
- Reference substance name:
- M-5925
- IUPAC Name:
- M-5925
- Test material form:
- other: M-5925 is a waxy solid (not specified in the report)
- Details on test material:
- Identification: M-5925
Test substance adminstered undiluted, warmed to 115°F (46°C), to liquefy
Purity: Not reported
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Not reported
- Age at study initiation: Not reported
- Weight at study initiation: 2.4 - 2.7 kg
- Fasting period before study: Not reported
- Housing: Not reported
- Diet (e.g. ad libitum): Not reported
- Water (e.g. ad libitum): Not reported
- Acclimation period: Not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported
- Humidity (%): Not reported
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): Not reported
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Undiluted DMOP was applied at 1260, 2000, 3160, 5010 and 7940 mg/kg (one animal per dose rate (male animals were dosed at 1260, 3160 and 7940 mg/kg; female animals were dosed at 2000 and 5010mg/kg) to the closely clipped, intact skin of New Zealand white male and female rabbits. The treated areas were covered with plastic strips and the animals held in wooden stocks for periods up to twenty four hours, after which time they were assigned to individual cages.
- Duration of exposure:
- 24 hours
- Doses:
- 1260, 2000, 3160, 5010 and 7940 mg/kg
- No. of animals per sex per dose:
- 1 animal per dose rate (male animals were dosed at 1260, 3160 and 7940 mg/kg; female animals were dosed at 2000 and 5010mg/kg).
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations were performed once daily, the weight change 5 days after dosing was recorded
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- Satistical analysis was not performed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LDLo
- Effect level:
- > 2 000 - < 3 160 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortality was observed at doses >2000 mg/kg (mortality at 3160, 5010 and 7940 mg/kg)
- Clinical signs:
- other: Toxic signs included reduced appetite and activity (two to four days in survivors), gradually increasing weakness, collapse (for period of 1 to 3 days), and death.
- Gross pathology:
- At autopsy there was lung congestion, liver discoloration, discoloration of kidneys and spleen, enlarged gall bladder, and gastrointestinal inflammation. Surviving animals were sacrificed at 14 days after dosing. Macroscopic examination revealed slight discoloration of kidneys.
Any other information on results incl. tables
Mortality and Weight Change
Animal No. - Sex |
Weight (kg) |
Dose (mg/kg) |
Weight Change (5 days after dosing) |
Fate |
1-Male |
2.4 |
1260 |
-0.1 |
Survived |
2-Female |
2.7 |
2000 |
-0.1 |
Survived |
3-Male |
2.5 |
3160 |
-0.5 |
Died – 12 days |
4-Female |
2.6 |
5010 |
-0.4 |
Died – 12 days |
5-Male |
2.5 |
7940 |
-0.5 |
Died – 10 days |
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The Acute Skin Absorption Minimal Lethal Dose for male and female rabbits was found to be > 2000 mg/kg and < 3160 mg/kg.
- Executive summary:
Undiluted DMOP was applied at 1260, 2000, 3160, 5010 and 7940 mg/kg (one animal per dose rate (male animals were dosed at 1260, 3160 and 7940 mg/kg; female animals were dosed at 2000 and 5010mg/kg) to the closely clipped, intact skin of New Zealand white male and female rabbits. The treated areas were covered with plastic strips and the animals held in wooden stocks for periods up to 24 hours, after which time they were assigned to individual cages. Observations were made for toxic signs and the viscera of the test animals were examined macroscopically.
Toxic signs included reduced appetite and activity (2 to 4 days in survivors), gradually increasing weakness, collapse (for period of 1 to 3 days) and death. Body weight changes at 5 days post-dose were 0.1, 0.1, 0.5, 0.4 and 0.5 kg at dose rates of 1260, 2000, 3160, 5010 and 7940 mg/kg, respectively. At autopsy there was lung congestion, liver discoloration, discoloration of kidneys and spleen, enlarged gall bladder and gastrointestinal inflammation. Surviving animals were sacrificed at 14 days after dosing. Macroscopic examination revealed slight discoloration of kidneys. The acute skin absorption Minimal Lethal Dose for male and female rabbits was found to be > 2000 mg/kg and < 3160 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.