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EC number: 246-904-0 | CAS number: 25371-54-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006-06-07 to 2006-08-04
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Dimethyl octadecylphosphonate
- EC Number:
- 246-904-0
- EC Name:
- Dimethyl octadecylphosphonate
- Cas Number:
- 25371-54-4
- Molecular formula:
- C20H43O3P
- IUPAC Name:
- dimethyl octadecylphosphonate
- Test material form:
- other: white solid
- Details on test material:
- Identification: Duraphos 100
Description: White solid
Batch: F14E002
Purity: 91.1% dimethyl octadecylphosphonate
Storage: Room temperature in the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sprague-Dawley CD
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
-Strain: Sprague-Dawley CD (Crl: CD® (SD) IGS BR)
-Sex: Female (nulliparous and non-pregnant)
- Source: Charles River (UK) Ltd
- Age at study initiation: 8-12 weeks old
- Weight at study initiation: bodyweights were in the range of 196 to 211 g on Day 0 (animals dosed at 2000 mg/kg bw)
- Housing: the animals were housed in groups of up to four*
- Diet: Certified Rat and Mouse Diet* (Code 5LF2) was available ad libitum (with the exception of an overnight fast immediately before dosing and for approximately 3 to 4 hours after dosing)
- Water (e.g. ad libitum): ad libitum*
- Acclimation period: The acclimatisation period was at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): target of 19 to 25°C**
- Humidity (%): target of 30 to 70%**
- Air changes (per hr): at least fifteen changes per hour
- Photoperiod (hrs dark / hrs light): 2 hours continuous light (06:00 to 18:00) and 12 hours darkness.
*The diet, drinking water and bedding were routinely analysed and were considered not to contain any contaminants that would reasonably be expected to affect the purpose or integrity of the study.
** Any occasional deviations from these targets were considered not to have affected the integrity of the study.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Details on oral exposure:
- All animals were dosed once with dimethyl octadecylphosphonate (DMOP) by oral gavage, using a metal cannula attached to a graduated syringe. The volume administered to each animal was calculated according to the fasted bodyweight at the time of dosing. Treatment of animals was sequential. Sufficient time was allowed between each dose level to confirm the survival of the previously dosed animals.
- Doses:
- single dose of 300 mg/kg or 2000 mg/kg
A single female was treated at 300 mg/kg. In the absence of toxicity at 300 mg/kg, another female was treated at 2000 mg/kg. In the absence of toxicity at 2000 mg/kg, an additional group of 4 females were treated at 2000 mg/kg. - No. of animals per sex per dose:
- 1♀ at 300 mg/kg
followed by 1♀ at 2000 mg/kg
followed by 4♀ treated at 2000 mg/kg (total of 5♀ at 2000 mg/kg) - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations were made at 0.5, 1, 2 and 4 hours after dosing and then daily for 14 days. Individual bodyweights were recorded on Day 0 (the day of dosing) and on Days 7 and 14.
- Necropsy of survivors performed: yes, all animals were subjected to gross necropsy. This consisted of an external examination and opening of the abdominal and thoracic cavities. The appearance of any macroscopic abnormalities was recorded. No tissues were retained.
Other observation: Morbidity and mortality checks were made twice daily. - Statistics:
- Statistical analysis was not performed.
Results and discussion
- Preliminary study:
- Toxicity was not observed when one female animal was treated with a dose of 300 mg/kg DMOP and another female was treated at 2000 mg/kg. In the absence of toxicity at 2000 mg/kg DMOP, an additional group of 4 females were treated at 2000 mg/kg DMOP.
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks:
- 91.1% dimethyl octadecylphosphonate
- Mortality:
- There were no deaths.
- Clinical signs:
- other: No signs of systemic toxicity were noted during the study.
- Gross pathology:
- No abnormalities were noted at necropsy.
- Other findings:
- None.
Any other information on results incl. tables
Individual Bodyweights and Bodyweight Changes - 300 mg/kg
Dose Level mg/kg |
Animal Number and Sex |
Bodyweight (g) at Day |
Bodyweight Gain (g) During Week |
|||
0 |
7 |
14 |
1 |
2 |
||
300 |
1-0 Female |
222 |
254 |
270 |
32 |
16 |
Individual Bodyweights and Bodyweight Changes - 2000 mg/kg
Dose Level (mg/kg) |
Animal Number and Sex |
Bodyweight (g) at Day |
Bodyweight Gain (g) at During Week |
|||
0 |
7 |
14 |
1 |
2 |
||
2000 |
2-0 Female |
196 |
223 |
247 |
27 |
24 |
3-0 Female |
207 |
230 |
247 |
23 |
17 |
|
3-1 Female |
211 |
232 |
255 |
21 |
23 |
|
3-2 Female |
210 |
239 |
254 |
29 |
15 |
|
3-3 Female |
205 |
232 |
257 |
27 |
25 |
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The acute oral median lethal dose (LD50) of DMOP in the female Sprague-Dawley CD strain rat was greater than 2000 mg/kg bodyweight.
- Executive summary:
An acute oral toxicity study was performed according to OECD Guidelines for Testing of Chemicals No 420 "Acute Oral Toxicity - Fixed Dose Method". Test material (91.1% dimethyl octadecylphosphonate (DMOP)) was administered to Sprague-Dawley CD strain female rats by oral gavage. Following a preliminary test in which there were no deaths at dose levels of 300 mg/kg and 2000 mg/kg, a further group of four fasted females was given a single oral dose of test material, as a suspension in arachis oil BP at a dose level of 2000 mg/kg bodyweight. Clinical signs and bodyweight development were monitored for 14 days after test material administration. All animals were subjected to gross necropsy.
There were no deaths or signs of systemic toxicity. All animals showed expected weight gains in bodyweight and no abnormalities were observed at necropsy. The acute oral median lethal dose (LD50) of DMOP in the female Sprague-Dawley CD strain rat was greater than 2000 mg/kg bodyweight.
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