Undec-10-enoic acid

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2008-09-05 till 2009-01-15

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Remarks:

Klimisch 2 only, since no pH data given in the report.

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to other study

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

4

Temp.:

22 °C

pH:

> 6 - < 9

Details on results:

Values were calculated as the mean of 3 determinations (see free text field below).

Tab. 1: Results of reference substances

Substances	Mean retention time (min)	log Pow
Formamide	1.27	-
Toluene	1.98	2.7
Ethyl benzene	2.34	3.2
Biphenyle	2.88	4.0
1,2,4-trichlorobenzene	3.28	4.2
Phenanthrene	3.83	4.5
Dibenzyle	4.09	4.8
Triphenylamine	6.18	5.7
DDT	7.55	6.2

Values were calculated as the mean of 3 determinations.

Tab. 2: Log Pow values of 10-UNDECENOIC AClD obtained for 3 determinations:

Injection	Mean retention time (min)	log Pow
1	2.92	4.0
2	2.92	4.0
3	2.92	4.0

They were calculated using the precedent regression equation with the corresponding retention time. The mean value of the log Pow is 4.0. This result issued from the 3 determinations is in the guideline tolerance for repeatability (+/- 0.1 log units.).

Conclusions:

The Partition Coefficient of 10-UNDECENOIC ACID log Pow is 4.0 (at 22 °C).

Executive summary:

The objective of this study was to determine the Partition Coefficient of the test item 10-UNDECENOIC AClD by applying the procedure described in the OECD Guideline 117 Partition Coefficient (noctanol/water), HPLC Method. Three replicate determinations (at 22 °C) show that for the Partition Coefficient of 10-UNDECENOIC ACID, the log Pow mean value is 4.0.

Log Pow 4.0 indicates a certain bioaccumulative potential of undecylenic acid in aquatic organisms. Log Pow 4.0 represents exactly the lower end of the log Pow range, which is relevant for classification of chronic aquatic toxicity properties according to GHS/CLP. Log Pow 4.0 also indicates a certain potential of the substance as to its adsorptive properties.

Description of key information

One study conducted in accordance with the OECD Test Guideline 117 (HPLC method) and GLP requirements is available. Three replicate determinations (at 22 °C) resulted in a mean log Pow value equal to 4.0.

Key value for chemical safety assessment

Log Kow (Log Pow):

4

at the temperature of:

20 °C