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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
No data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
some study details missing, including TS purity.
Principles of method if other than guideline:
To investigate the potential toxicity of a single dose of the test substance.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-(trimethoxysilyl)propiononitrile
EC Number:
219-764-3
EC Name:
3-(trimethoxysilyl)propiononitrile
Cas Number:
2526-62-7
Molecular formula:
C6H13NO3Si
IUPAC Name:
3-(trimethoxysilyl)propiononitrile
Constituent 2
Reference substance name:
3-(trimethoxysilyl)propionitrile
IUPAC Name:
3-(trimethoxysilyl)propionitrile

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: 200-300 g
- Fasting period before study: Yes, overnight
- Housing: No data
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: No data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data

IN-LIFE DATES: No data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
MAXIMUM DOSE VOLUME APPLIED: 16 ml/kg
Doses:
4, 8 and 16 ml/kg bw
No. of animals per sex per dose:
Five
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily, and weighing on days 0, 7 and 14.
- Necropsy of survivors performed: yes, gross examination.
Statistics:
LD50 calculated using moving average method.

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
9.85 mL/kg bw
Based on:
test mat.
95% CL:
>= 7.15 - <= 13.6
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
11.3 mL/kg bw
Based on:
test mat.
95% CL:
>= 6.43 - <= 19.9
Mortality:
No deaths occurred in the lowest dose group. One male and one female died in the mid dose group (by day 5), and at the highest dose only one female survived the 14 day observation period (all animals died by six).
Clinical signs:
Signs of toxicity included sluggishness, unsteady gait and prostration.
Body weight:
No effects.
Gross pathology:
Necropsy revealed gas, liquid or solid filled stomachs and intestines, enlarged kidneys and dark lungs.
Other findings:
None

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In an acute oral gavage study, not conducted to GLP (reliability score 2), the oral LD50 for 3-(trimethoxysilyl)propionitrile in rats was 9.85 ml/kg bw for males and 11.3 ml/kg bw for females (9555 mg/kg bw and 10961 mg/kg bw, respectively, based on relative density of 0.97 g/cm3). Signs of toxicity included sluggishness, unsteady gait and prostration. Necropsy revealed gas, liquid or solid filled stomachs and intestines, enlarged kidneys and dark lungs.