3-methoxy-3-methylbutan-1-ol

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

bioaccumulation in aquatic species: fish

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance has a low potential for bioaccumulation based on log Kow <=3

Reference 2

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Study period:

2012

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

According to REACH Annex VIII column 2, bioaccumulation testing can be waived for substances with a low potential for bioaccumulation (log Kow < 3). MMB has a log Kow < 1. Hence, bioaccumulation testing can be waived for this substance.
A QSAR calculation was done for the bioconcentration factor of MMB using BCFBAF v3.01 (as available in US EPA EPISUITE). It resulted in an estimated log BCF of 0.5 (BCF = 3.16 L/kg ww). The BCF for MMB is < 2000 L/Kg ww and therefore bioaccumulation of this substance is not expected

Principles of method if other than guideline:

QSAR calculation using EPISUITE BCFBAF v3.01 (2012)

Key result

Type:

BCF

Value:

3.16 L/kg

Basis:

whole body w.w.

Validity criteria fulfilled:

yes

Conclusions:

The predicted log BCF = 0.5 (3.16 L/kg) based on measured log Pow = 0.18.

Description of key information

Estimated log BCF = 0.500 (BCF = 3.16 L/kg ww)

Key value for chemical safety assessment

BCF (aquatic species):

3.16 L/kg ww

Additional information

According to REACH Annex VIII column 2, bioaccumulation testing can be waived for substances with a low potential for bioaccumulation (log Kow < 3). MMB has a log Kow < 1. Hence, bioaccumulation testing can be waived for this substance.

A QSAR calculation was done for the bioconcentration factor of MMB using BCFBAF v3.01 (as available in US EPA EPISUITE). It resulted in an estimated log BCF of 0.5 (BCF = 3.16 L/kg ww). The BCF for MMB is < 2000 L/Kg ww and therefore bioaccumulation of this substance is not expected.