3-methoxy-3-methylbutan-1-ol

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2001

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

GLP compliance:

yes

Type of method:

flask method

Partition coefficient type:

octanol-water

Analytical method:

gas chromatography

Type:

log Pow

Partition coefficient:

0.18

Temp.:

24.8 °C

pH:

6.4

Results of the measurement of partition coefficient

			POW=CO/CW	log POW
				Measured value	Mean value	Total mean value
Measured condition 1		a	1.50	0.18	0.17	0.18 Standard deviation = 0.016Maximum difference = 0.03
		b	1.48	0.17
Measured condition 2		a	1.57	0.20	0.19
		b	1.50	0.17
Measured condition 3		a	1.60	0.20	0.19
		b	1.47	0.17

Results of pH measurement of water phase

	Measurement value
	Sample a	Sample b
Measured condition 1	6.6	6.3
Measured condition 2	6.5	6.3
Measured condition 3	6.4	6.3

Conclusions:

In conclusion, the log octanol/water partition coefficient value of 0.18 at 24.8°C and pH 6.3 was obtained for 3-methoxy-3-methylbutan-1-ol using the shake-flask method.

Description of key information

Log Kow: 0.18 at 25°C

Key value for chemical safety assessment

Log Kow (Log Pow):

0.18

at the temperature of:

25 °C

Additional information

A partition coefficient Octanol/Water Log Kow = 0.18 at 24.8°C was reported in a reliable study, conducted according to an appropriate test protocol.