Fatty acids, C9-13-neo-, zinc salts

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Acceptable, well-documented study report equivalent or similar to OECD guideline (403): pre-GLP.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1964

Report date:

1964

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

No analytical concentration measurements.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Neodecanoic acid

EC Number:

248-093-9

EC Name:

Neodecanoic acid

Cas Number:

26896-20-8

Molecular formula:

C10H20O2

IUPAC Name:

2-ethyl-2,5-dimethylhexanoic acid

Test animals

Species:

other: mouse, rat, and guinea pig

Strain:

other: Swiss, Wistar, and Hartley

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: no data provided
- Age at study initiation: no data provided
- Weight at study initiation: no data provided
- Fasting period before study: 3-4 hours
- Housing: groups
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 14 days

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: stainless steel gassing chamber
- Exposure chamber volume: 500 l
- Method of holding animals in test chamber: n/a
- Source and rate of air: forced room air
- Method of conditioning air: glass bubblers

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

6 h

Concentrations:

3 mg/l nominal concentration

No. of animals per sex per dose:

10 males per species

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days (or other?) Every 30 minutes during exposure and daily thereafter for 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights

Statistics:

No data analyzed.

Results and discussion

Effect levels

Effect levels 1

Sex:

male

Dose descriptor:

LC50

Effect level:

> 3 mg/L air (nominal)

Exp. duration:

6 h

Remarks on result:

other: mice and rats

Effect levels 2

Sex:

male

Dose descriptor:

LC50

Effect level:

< 3 mg/L air (nominal)

Exp. duration:

6 h

Remarks on result:

other: guinea pig

Mortality:

2 guinea pigs died on the 2nd day, 1 on the 13th, and 2 on the 14th post exposure.
All mice and rats survived.

Clinical signs:

other: No significant signs of respiratory irritation were noted. Alopecia and some weight loss were noted in the guinea pigs during the 14-day observation period.

Body weight:

Not analyzed.

Gross pathology:

No significant findings.

Applicant's summary and conclusion

Interpretation of results:

other:

Remarks:

Criteria used for interpretation of results: EU

Conclusions:

The acute inhalation LC50 for isononanol is >3 mg/l for mice and rats.

Executive summary:

Neodecanoic acid was administered via a vapor inhalation to 10 each of mice, rats, and guinea pigs at the nominal concentration of 3 mg/l for 6 hours.  Clinical observations were made every 30 minutes during the exposure and daily thereafter for 14 days.  No significant signs of respiratory irritation were noted.  Alopecia and some weight loss were noted in the guinea pigs during the 14-day observation period.  Two guinea pigs died on the 2nd day, 1 on the 13th, and 2 on the 14th post exposure.  All mice and rats survived.  Based on these data it is concluded that the LC50 for mice and rats is greater than 3 mg/l.