Registration Dossier
Registration Dossier
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EC number: 223-453-8 | CAS number: 3900-45-6
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- β-methyl naphthyl ketone
- Author:
- Opdyke DLJ
- Year:
- 1 975
- Bibliographic source:
- Food and Cosmetics Toxicology, Volume 13, Issue 6, Page 867
Materials and methods
- Principles of method if other than guideline:
- Maximization test
- GLP compliance:
- not specified
- Type of study:
- other: Maximization test
Test material
- Reference substance name:
- 2'-acetonaphthone
- EC Number:
- 202-216-2
- EC Name:
- 2'-acetonaphthone
- Cas Number:
- 93-08-3
- Molecular formula:
- C12H10O
- IUPAC Name:
- 1-(2-naphthyl)ethanone
- Details on test material:
- - Name of test material (as cited in study report): 2'-acetonaphthone
- Substance type: Organic
- Physical state: Solid
Constituent 1
In vivo test system
Test animals
- Species:
- human
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: no data
- Vehicle:
- petrolatum
- Concentration / amount:
- 2 %
Challenge
- Concentration / amount:
- 2 %
- No. of animals per dose:
- 25
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 2%
- No. with + reactions:
- 0
- Total no. in group:
- 25
- Clinical observations:
- no sensitization reactions
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Dose level: 2%. No with. + reactions: 0.0. Total no. in groups: 25.0. Clinical observations: no sensitization reactions.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Acetophenone was assessed as non-sensitiser in a Maximization test with humans.
- Executive summary:
The maximization test was carried out on 25 volunteers. The material was tested at a concentration of 2% in petrolatum and produced no sensitization reactions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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