(1-methylethyl)-1,1'-biphenyl

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study meets basic scientific principles; comparable to guideline study; basic data given

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

; 10 animals per dose level, no pathology, only one sex tested, limited reporting

GLP compliance:

no

Remarks:

pre-GLP stuidy

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

(1-methylethyl)-1,1'-biphenyl

EC Number:

247-156-8

EC Name:

(1-methylethyl)-1,1'-biphenyl

Cas Number:

25640-78-2

Molecular formula:

C15H16

IUPAC Name:

(1-methylethyl)-1,1'-biphenyl

Details on test material:

- Name of test material (as cited in study report): Sun oil X489-17B
- no further information

Test animals

Species:

rat

Strain:

Wistar

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 200 - 300 g
- Fasting period before study: 24 h
- Animals were fed, housed and watered in accordance with standard laboratory procedures.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Doses:

1, 3, 5, 8, 10, and 15 g/kg bw

No. of animals per sex per dose:

10

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations at 1, 3, 6, 24, 48, 72 h, and daily thereafter; no information on weighing
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs

Statistics:

LD 50 was determined in accordance with the method of Miller and Tainter (Proc. Soc. Exp. Biol. Med. NY , 57, 261-264, 1944)

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

4 650 mg/kg bw

Based on:

test mat.

Remarks on result:

other: S.E. = 640 mg/kg bw

Clinical signs:

other: Decreased locomotor activity, piloerection, ataxia, ptosis. In the lowest dose group, slight systemic toxicity prevalently related to CNS effects (decreased locomotor activity) was observed. 4 days after treatment, the test animals appeared normal again.

Gross pathology:

no data

Other findings:

--

Any other information on results incl. tables

Mortality

 

Dose [g/kg bw]	Animals per Group	Day			Total
		2	3	4
1	10	0	0	0	0/10
3	10	0	1	1	2/10
5	10	0	4	2	6/10
8	10	2	5	1	8/10
10	10	3	3	2	8/10
15	10	0	3	7	10/10

 

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Monoisopropylbiphenyl is only slightly acute toxic. LD50 was determined to be 4650 mg/kg bw. Classification according EU regulations is not required.