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EC number: 247-156-8 | CAS number: 25640-78-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
In a ready biodegradation test according to OECD TG 310 >= 60% ultimate biodegradation based on CO2 evolution was determined, but the criterion of reaching the cut-off limit for ready biodegradability within 10 days was not met. But the degradation kinetics represented by CO2 evolution clearly supports ready biodegradability under environmental conditions.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable but failing 10-day window
Additional information
Biodegradation of (1-methylethyl)-1,1'-biphenyl was examined in three tests, only one of them is considered to be valid, suitable for assessment: Ready biodegradability was tested in a recent fully valid study according to OECD TG 310 OECD [CO2 in Sealed Vessels (Headspace Test)] (Fiebig/NOACK 2013) and in a non-verifiable modified MITI (I) test according to OECD TG 301 C (Handley/Safepharm 1994).
The third test was carried out not following a test guideline (Mendoza/DOW 1981), but the method used was similar to a closed bottle test, however using an initial test concentration of about 0.2 mg/L close to its maximum water solubility, however too low for this test method.
In the OECD 310 study of Fiebig/NOACK, 67% ultimate biodegradation (CO2 evolution) was determined during a 43 day test period. Within 28 days, about 60 % biodegradation was observed with a time window of 18-20 days. In this study, isopropylbiphenyl proved to degrade rapidly but the strict criteria for ready biodegradation were just missed, while primary degradation based on GC analysis was almost complete after 6 days (97 %).
In the study of Handley/Safepharm 1994, only 1% ultimate biodegradation (O2 consumption) was observed. Primary consumption of test material was determined to be 67% averaged over the three replicates. Due to its low water solubility (ca. 0.5 mg/L), the test substance was dissolved only to a slight extent (initial test substance concentration 100 mg/L). Test material was floating in globules on the surface of the test media until termination of the test.
In the study of Mendoza/Dow 1981, test substance concentrations were quite low (0.184 mg/L) falling within the range of water solubility of the substance. In this test, biodegradation of ca. 70% based on O2 consumption was apparently obtained within 10 days. But the sensitivity of the test has to be questioned.
Isopropylbiphenyl is considered to be a difficult to test substance in biodegradability tests due to its low water solubility. Depending on test conditions, more or less biodegradation will be observed. Test conditions of the modified MITI (I) test are unfavourable for isopropylbiphenyl biodegradation. This test will be disregarded. The results of the OECD 310 study are considered to be characteristic of the inherent properties of isopropylbiphenyl. On this basis, isopropylbiphenyl is graded as readily biodegradable but failing the 10-day window.
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