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EC number: 295-551-9 | CAS number: 92062-36-7
Endpoint summary
Administrative data
Description of key information
Repeated Dose Oral 90d – NOAEL = 600 mg/kg bw for rats (similar to OECD TG 408)
Repeated Dose Inhalation 90d – NOAEL = 1800 mg/m3 for rats (similar to OECD TG 413)
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 600 mg/kg bw/day
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 1 800 mg/m³
Additional information
Oral: Hydrocarbons, C9 aromatics are expected to have a low order of repeated dose toxicity by the oral route of exposure. All tests were performed in a manner similar or equivalent to currently established OECD guidelines. In a repeated dose study where the test substance, Hydrocarbons, C9 aromatics, was administered via oral gavage, no toxicity was observed and characterized at the highest dose tested of 600 mg/kg. Based on this observation, the repeat oral dose NOAEL is 600 mg/kg for C9 Aromatics.Inhalation: In a 12 month chronic study where Hydrocarbons, C9 aromatics were administered via inhalation, no signs of toxicity were observed at the maximum concentration. Based on these observations, the repeat inhalation concentration NOAEL is
1800 mg/m3 for the Hydrocarbons, C9, aromatics.
Justification for classification or non-classification
C9 Aromatics are expected to have a low order of repeated dose toxicity by the oral route of exposure. All tests were performed in a manner similar or equivalent to currently established OECD guidelines. In a repeated dose study where the test substance, Hydrocarbons, C9 aromatics, was administered via oral gavage, no toxicity was observed and characterized at the highest dose tested of 600 mg/kg. Based on this observation, the repeat oral dose NOAEL is 600 mg/kg for Hydrocarbons, C9 aromatics. In a 12 month chronic study where Hydrocarbons, C9 Aromatics were administered via inhalation, no signs of toxicity were observed at the maximum concentration. Based on these observations, the repeat inhalation concentration NOAEL is 1800 mg/m3 Hydrocarbons, C9 aromatics. These findings do not warrant the classification of C10-C12 Aromatics as a repeated dose toxicant under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
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