Registration Dossier
Registration Dossier
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EC number: 202-797-2 | CAS number: 99-88-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given (comparable to standards)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-isopropylaniline
- EC Number:
- 202-797-2
- EC Name:
- 4-isopropylaniline
- Cas Number:
- 99-88-7
- Molecular formula:
- C9H13N
- IUPAC Name:
- 4-(propan-2-yl)aniline
- Details on test material:
- - Name of test material (as cited in study report): 4-(1-Methylethyl)aniline
- Analytical purity: 99.27 wt%
- Physical state: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 700, 910, 1183, 1538 and 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 985 mg/kg bw
- Mortality:
- At 910 mg/kg and more deaths occured within both sexes.
- Clinical signs:
- other: In animals in all the groups, abnormal gait, decreased spontaneous motor activity and salivation were observed in both sexes. Lachrymation and adoption of a prone, lateral position and/or hunched back position were observed in both sexes receiving 910 mg/
Any other information on results incl. tables
No further details were reported.
Applicant's summary and conclusion
- Interpretation of results:
- sligthly toxic
- Remarks:
- Xn R22 Criteria used for interpretation of results: EU
- Conclusions:
- Risk of methaemoglobin formation even after skin or oral contact (leads to increased classification).
Symptoms may be delayed. - Executive summary:
The LD50 for 4-isopropylaniline is 985 mg/kg bw. 4-isopropylaniline has the risk of methaemoglobin formation after skin and or oral contact. The conducted study followed the OECD guideline 401.
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