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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15/09/2006 - 07/03/2007
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP, Guideline study.
Qualifier:
according to guideline
Guideline:
OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)
Deviations:
not specified
Principles of method if other than guideline:
No data reported
GLP compliance:
yes
Type of method:
other: slow-stirring method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
> 5.2
Temp.:
20 °C
pH:
7
Details on results:
Standard temperature and pressure assumed.

As the aqueous test samples do not show any peak at the relevant retention time, the measured concentration can be assumed to be lower than 2.0387 µg/mL (equal to a concentration of <0.2 µg/mL by taking the concentration factor into account). Using this value, the calculated log Pow is >5.2.

Conclusions:
The log partition coefficient of polysulfide di-tert-nonyl is reported to be > 5.2
Executive summary:

Weissenfeld (2007) is a GLP-compliant, slow stirring, octanol-water study with high performance liquid chromatography analytical monitoring, following OECD guideline 123. The study is considered reliable and suitable for use for this endpoint.

Description of key information

The log partition coefficient of polysulfide di-tert-nonyl is reported to be > 5.2

Key value for chemical safety assessment

Log Kow (Log Pow):
5.2
at the temperature of:
20 °C

Additional information

As the aqueous test samples do not show any peak at the relevant retention time, the measured concentration can be assumed to be lower than 2.0387 µg/mL (equal to a concentration of <0.2 µg/mL by taking the concentration factor into account). Using this value, the calculated log Pow is >5.2.

The key result is from Weissenfeld (2007) which is a GLP-compliant, slow stirring, octanol-water study with high performance liquid chromatography analytical monitoring, following OECD guideline 123. The study is considered reliable and suitable for use for this endpoint.