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Diss Factsheets
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EC number: 413-110-2 | CAS number: 135861-56-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: LD50 > 5000 mg/kg bw, OECD Guideline 401
Acute dermal toxicity: LD50 > 2000 mg/kg bw, OECD Guideline 402
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- The available studies are GLP compliant and have been scored with Klimisch 1 reliability.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- The available studies are GLP compliant and have been scored with Klimisch 1 reliability.
Additional information
This substance has been investigated in two acute oral toxicity studies and two acute dermal studies. All studies consistently show absence of mortality and target organ toxicity. All studies were performed according to GLP and OECD guidelines.
For acute oral toxicity, the two studies available were performed with doses of up to 5000 mg/kg bw studied with male and female rats of different strains (Albino rats and Crl CDBR). The test animals were feeded with the substance in oral gavage. No mortality and no treatment-related clinical signs were recorded in any of the two studies. As a conclusion, acute oral toxicity is therefore considered low.
For acute dermal toxicity, the two studies available were performed with rats (Sprague Dawley). In both studies, the substance was appliead in a semi-occlusive coverage with vehicles liquid paraffine and arachis oil respectively. The substance applied was 2000 mg/kg and after the observation period of 24h there was no mortality, no clinical signs and no effect on body weight gain. Any dermal effects were observed during the treatment or after. As a conclusion, acute dermal toxicity is therefore considered low.
There isnt't any acute inhalation toxicity study available. This exposure route has been considered as non likely to occur.
Justification for selection of acute toxicity – oral endpoint
There are two test results available, with same results.
Justification for selection of acute toxicity – inhalation endpoint
Data waiving: exposure route not likely to occur.
Justification for selection of acute toxicity – dermal endpoint
There are two test results available, with same results.
Justification for classification or non-classification
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. The values obtained have been compared to the limit values as stated in the Annex I of the Regulation (table 3.1.1.). As a result the substance is not considered to be classified for acute toxicity under Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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