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EC number: 239-491-3 | CAS number: 15471-17-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Short - term toxicity to aquatic species
Acute or so-called short-term toxicity experiments were conducted with fish (Rainbow trout, species unknown) and daphnids (Daphnia magna). Both experiments were conducted under certificated Good Laboratory Practice (GLP) compliance and are classified as key studies with reliability Klimisch 1. The test with freshwater trouts was performed according to OECD Guideline 203 in a flow-through mode by Heisler (1990). The test duration was 96 hours with substance concentrations of 100 mg/L as well as 1000 mg/L. No reference substance was used since it is not essential according to the guideline description. All animals were inconspicuous and no animal died. During macroscopic autopsy no experimental-specific findings were observed. According to these result the LC50 as well as the NOEC is determined to be > 1000 mg/L. Therefore, the test substance has not to be classified as toxic to fish.
OECD Guideline 202 (EU Method C.2) was applied in a static freshwater test with Daphnia magna as test organism (Wetton and Mullee, 2001). The test duration was 48 hours with a substance concentration of 100 mg/L, which was selected based on the preliminary range-finding study. No reference substance was used since it is not essential according to the guideline description. No immobility of daphnids was detected at the tested concentration, thus as result an EC50 (48h) > 100 mg/L and a NOEC value of 100 mg/L was reported. It was considered unnecessary and unrealistic to test at concentrations in excess of 100 mg/L. Considering these results, the test substance has not to be classified as toxic to aquatic invertebrates.
Concerning green algae the acute toxicity was predicted by the computer program ECOSAR v1.00, resulting in an EC50(96h) value of 26.70 g/L (Chemservice S.A., 2011). This procedure is scientifically accepted, therefore the result is taken into account for the risk assessment and does not lead to a classification and corresponding labelling of the substance according to CLP regulation.
Long - term toxicity to aquatic species
No experimental data exist for the test substance regarding chronic or so-called long-term toxicity for the aquatic environment. One approach is to calculate the "Chronic Value (ChV)" for three relevant species (e.g. fish, daphnids and green algae) by using the computer software EPIWIN/ECOSAR v1.00 of the US-EPA. The program uses an extensive set of structure-activity relationships (SARs) to estimate the toxicity of chemicals discharged to water, whereby the ChV is defined as the geometric mean of the No Observed Effect Concentration (NOEC) and Lowest Observed Effect Concentration (LOEC). For this procedure no GLP compliance criteria are applicable, however, it is regarded as a scientifically accepted calculation method. Therefore, the results can be considered as reliable with restrictions (Klimisch 2). However, the results cannot be taken into account for the chemical safety assessment.
For fish, a ChV of 45.8 g/L was predicted, for daphnids a value of 14.4 g/L and for green algae (species not further specified) a Chronic Value of 6.3 g/L is reported (Chemservice S.A., 2011). These values indicate that no toxicity concern arises for the different trophic levels.
Toxicity to microorganisms
A mixed population of activated sewage sludge microorganisms was used to test the toxicity towards aquatic microorganisms according to OECD Guideline 209 (Wadsley, 2012). Test substance concentrations of 10, 100 and 1000 mg/L were used. The exposure period was 3 hours at a temperature of 20 +/- 2 °C with addition of synthetic sewage as respiratory substrate. The EC50(3h) was found to be greater than 1000 mg/L with a corresponding No Observed Effect Concentration (NOEC) of 1000 mg/L.
Supporting information is given by an experiment according to Bringmann and Kühn (1977) with Pseudomonas putida (Oláh and Kiss, 1990). As result a MIC (Minimum Inhibitory Concentration) of 0.12 g/mL is reported, which can neither be used for the chemical safety assessment nor for the risk assessment.
Toxicity to other aquatic plants than algae and other aquatic organisms
This information is not available and / or not required under REACH.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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