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Diss Factsheets
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EC number: 443-800-9 | CAS number: 40031-31-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29-09-2003
- Reliability:
- 1 (reliable without restriction)
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- ISO 6341 (Water quality - Determination of the Inhibition of the Mobility of Daphnia magna Straus (Cladocera, Crustacea))
- Version / remarks:
- ISO International Standard 6341 : 'Water quality — Determination of the inhibition of the mobility of Daphnia magna Straus — Acute toxicity test, Third edition, 1996-04-01.
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- OECD guideline No. 202 Part l: "Daphnia sp., Acute Immobilisation Test", Adopted April 4, 1984.
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- EEC directive 92/69, Part C: Methods for the determination of ecotoxicity, Publication No. L383, December 1 992, C.2. "Acute Toxicity for Daphnia"
- Deviations:
- no
- Principles of method if other than guideline:
- NA
- GLP compliance:
- yes
- Specific details on test material used for the study:
- NA
- Analytical monitoring:
- yes
- Details on sampling:
- Frequency: at t=0h and t=48h
Volume: 10 mL from the approximate centre of the test vessel - Vehicle:
- yes
- Details on test solutions:
- Preparation of test solutions started with stock solutions in test medium at 100 mg/l. No special treatment other than a magnetic stirring period of ca. 20 minutes was necessary to completely dissolve the test substance in the test medium. The lower test concentrations were prepared by subsequent dilution of the stock in test medium. All final test solutions were clear and colourless
Nominal test concentrations: 0.1 , 1 .0, 10 and 100 mg/l.
Blank-control Test medium without test substance or other additives (O mg/l). - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnids originated from a healthy stock, 2nd to 5th brood, showing no signs of stress such as mortality >20%, presence of males, ephippia or discoloured animals and there was no delay in the production of the first brood.
For the test selection of young daphnia with an age of < 24 hours, from parental daphnids of more than two weeks old. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- NA
- Post exposure observation period:
- NA
- Hardness:
- 250 mg/l expressed as CaC03 and the pH: 8.0 ± 0.2 after aeration.
- Test temperature:
- The temperature of the test medium was 20.5 °C at the start of the test. The temperature continuously measured in a temperature control vessel varied between 20.2 and 20.7°C during the test, and complied with the requirements as laid down in the protocol (18-22°C, constant within 2°C).
- pH:
- pH: 6.0-8.5
- Dissolved oxygen:
- oxygen: >7 mg/l at the start, 25 mg/l at the end of the test
- Salinity:
- NA
- Conductivity:
- NA
- Nominal and measured concentrations:
- Analysis of the samples taken during the test showed that the measured concentration was in agreement with nominal (97-99%).
- Details on test conditions:
- NA
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate (K2Cr207)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Under the conditions of the present study (S)-1,3,4-trihydroxybutan-2-one did not induce acute immobilisation of Daphnia magna at 100 mg/l after 48 hours of exposure (NOEC). Erythruolose did not induce acute immobilisation of Daphnia magna at 100 mg/l after 48 hours of exposure (NOEC).
- Results with reference substance (positive control):
- The 24h-EC50 of potassium dichromate was 1.2 mg/l with a 95% confidence interval between 1.0 and 1.5 mg/l.
The 48h-EC50 of potassium dichromate was 0.60 mg/l with a 95% confidence interval between 0.52 and 0.76 mg/l. - Reported statistics and error estimates:
- NA
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of the present study (S)-1,3,4-trihydroxybutan-2-onedid not induce acute immobilisation of Daphnia magna at 100 mg/l after 48 hours of exposure (NOEC). (S)-1,3,4-trihydroxybutan-2-one did not induce acute immobilisation of Daphnia magna at 100 mg/l after 48 hours of exposure (NOEC).
- Executive summary:
Under the conditions of the present study (S)-1,3,4-trihydroxybutan-2-one did not induce acute immobilisation of Daphnia magna at 100 mg/l after 48 hours of exposure (NOEC). Erythruolose did not induce acute immobilisation of Daphnia magna at 100 mg/l after 48 hours of exposure (NOEC).
Reference
No remarks
Description of key information
Under the conditions of the present study (S)-1,3,4-trihydroxybutan-2-one did not induce acute immobilisation of Daphnia magna at 100 mg/l after 48 hours of exposure (NOEC). (S)-1,3,4-trihydroxybutan-2-one did not induce acute immobilisation of Daphnia magna at 100 mg/l after 48 hours of exposure (NOEC).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- > 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.