Registration Dossier
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EC number: 701-394-3 | CAS number: 1782069-81-1
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 August 2017 - 05 September 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Key result
- Water solubility:
- 1.08 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 5 - 6
- Details on results:
- According to the test guideline five consecutive samples should not differ in concentration by more than ±30 % and the mean values obtained from two tests with different flows should not differ by more than 30 %. These criteria were fulfilled and therefore, the study is valid.
- Conclusions:
- The water solubility of the test item was found to be 1.08 ± 0.15 mg/L at 20 °C.
- Executive summary:
The water solubility of the test item was determined using the column elution method. The water solubility was found to be 1.08 ± 0.15 mg/L at 20 °C (pH 5 -6). The study was conducted according to OECD Method 105 and was GLP-compliant, therefore it is considered to be reliable without restriction (Klimisch 1).
Reference
Table 1. Results for the determination of water solubility
| Test number | Flow rate (mL/h) | Water solubility (mg/L) |
| 1 | 41 | 1.11 |
| 1 | 41 | 0.888 |
| 1 | 41 | 1.19 |
| 1 | 41 | 1.14 |
| 1 | 41 | 1.02 |
| Average of test 1 | 41 | 1.07 ± 0.12 |
| 2 | 21 | 0.909 |
| 2 | 21 | 1.17 |
| 2 | 21 | 0.895 |
| 2 | 21 | 1.15 |
| 2 | 21 | 1.30 |
| Average of test 2 | 21 | 1.09 ± 0.18 |
| Average of tests 1 and 2 | - | 1.08 ± 0.15 |
Description of key information
The water solubility of the test item was determined using the column elution method. The water solubility was found to be 1.08 ± 0.15 mg/L at 20 °C (pH 5 -6).
Key value for chemical safety assessment
- Water solubility:
- 1.08 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item was determined using the column elution method. The water solubility was found to be 1.08 ± 0.15 mg/L at 20 °C (pH 5 -6) (2017). The study was conducted according to OECD Method 105 and was GLP-compliant, therefore it is considered to be reliable without restriction (Klimisch 1).
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