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Diss Factsheets
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EC number: 220-239-6 | CAS number: 2682-20-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Stability: thermal, sunlight, metals
Administrative data
- Endpoint:
- stability: thermal, sunlight, metals, other
- Remarks:
- Migrated from section 'Stability: thermal, sunlight, metals'
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February - July 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to guidelines but was conducted according to GLPs and the report contains sufficient data for interpretation of study results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: ASTM Method E-537-86 for thermal stability
- Deviations:
- not specified
- Qualifier:
- no guideline followed
- Guideline:
- other: for stability to sunlight
- Deviations:
- not specified
- Qualifier:
- no guideline followed
- Guideline:
- other: for stability around metal
- Deviations:
- not specified
- Principles of method if other than guideline:
- For stability to sunlight, the test material was kept in the dark and exposed to artificial sunlight for 72 hours. Samples were analyzed by HPLC.
For stability around metal, the test material was analyzed in the presence of mild steel coupons. - GLP compliance:
- yes
Test material
- Test material form:
- other: solid
- Details on test material:
- All Series 63 characterizations of Kordek 573T Industrial Microbicide were done using the Technical Grade Active Ingredient (TGAI). The test material consisted of >95% 2-methyl-4-isothiazol-3-one. Impurities ranged from 0.1 to 1.0% and total less than 5.0%.
Constituent 1
Results and discussion
For thermal stability study
- Test substance thermally stable:
- yes
Operating temperature
- Operating temp.:
- < 160 °C
- Remarks on result:
- other: At temperatures above 160C, major exothermic decomposition can be observed with extrapolated onset temperatures of between 222C and 226C and peak temperatures between 235C and 238C.
- Transformation products:
- yes
For study on stability to sunlight
- Test substance stable to sunlight:
- yes
For study on stability to metals
- Test substance stable to metals / metal ions:
- no
Any other information on results incl. tables
Thermal stability
None of the samples exhibited evidence of significant exothermic behavior at temperatures before 160C. At temperatures above 160C, major exothermic decomposition can be observed with extrapolated onset temperatures of between 222C and 226C and peak temperatures between 235C and 238C.
Thermal Stability by TGA for Kordek 573T
Onsets TC | |||
Lot # | "true" | extrapolated | Peak TC |
1026 -DSC | 161 | 222 | 235 |
1028 -DSC | 172 | 226 | 240 |
1029 -DSC | 160 | 223 | 237 |
1031 -DSC | 160 (142)* | 222 | 237 |
* Base line noise made the exact determination of the "true onset" difficult.
Sunlight Exposure
The F-test for differences among the seven means is significant (F = 16.47, p = 0.0085). The "0 hr/no sun" (control), "72 hr/sun" and "72 hr/no sun" means are not statistically different from each other, but they are different from the other means. The other means (24hr/sun, 24 hr/no sun, 48 hr/sun, 48 hr/no sun) are not statistically different from each other. There may be some other factor that is causing these significant differences. The statistical differences found do not follow the patterns one would expect if exposure and/or storage time degraded percent active ingredient. It is clearly not the exposure to sunlight since exposed and non-exposed samples stored for the same length of time are not statistically different. It is also not do to the length of exposure since the 72 hours samples are not statistically different than the control. The differences may be due to day-to-day testing variation or the sampling of the lot of product.
The regression analysis shows there is no statistically significant trend in the exposure time for both the sunlight exposed or not exposed samples. There is no statistical evidence to show an effect of exposure time on the percent active ingredient of the tested samples.
Stability to Sunlight
Sample ID | Exposure Time | Foil Covered | Average PPM RH-573 (Std Dev) |
R95 -338 -1 | 24 hours | yes | 97.14 (0.235) |
R95 -338 -20 | 24 hours | yes | 97.04 (0.142) |
R95 -338 - 21 | 24 hours | no | 97.34 (0.174) |
R95 -338 -22 | 24 hours | no | 97.22 (0.100) |
R95 -338 -23 | 48 hours | yes | 97.46 (0.244) |
R95 -338 -24 | 48 hours | yes | 97.08 (0.180) |
R95 -338 -25 | 48 hours | no | 97.13 (0.239) |
R95 -338 -26 | 48 hours | no | 97.55 (0.162) |
R95 -338 -27 | 72 hours | yes | 98.75 (0.103) |
R95 -338 -28 | 72 hours | yes | 98.02 (0.081) |
R95 -338 -29 | 72 hours | no | 98.16 (0.571) |
R95 - 338 -30 | 72 hours | no | 97.98 (0.163) |
R95 - 338 -31 | no exposure | -- | 98.80 (0.094) |
Stability to metal
The F-test for differences among the means is significant (F=23.78 p=0.0404). The no metal and control least square means (96.21 and 95.98%AI) are not statistically different, but both differ significantly (p-value<0.05) from the metal mean (93.14%AI). The presence of metal does significantly reduce the percent active ingredient of the Kordek 573T samples.
Stability in the presence of metal
No Heat, No Metal | Heat (50C), No Metal | Heat (50C) + Metal | ||||
Lot No. | Mean | Grand Mean | Mean | Grand Mean | Mean | Grand Mean |
1029 | 96.7 | --- | 97.2 | --- | 94.6 | --- |
1031 | 95.3 | --- | 95.3 | --- | 91.7 | --- |
Lots combined | --- | 96.0 | --- | 96.3 | --- | 93.2 |
Note Numbers are slightly different in this Summary Table from numbers in text.
Applicant's summary and conclusion
- Conclusions:
- At temperatures above 160C, major exothermic decomposition can be observed with extrapolated onset temperatures of between 222C and 226C and peak temperatures between 235C and 238C. The test material was stable to sunlight but was not stable in the presence of metal at 50C for one week.
- Executive summary:
Stability in the presence of heat, sunlight and metal was determined. At temperatures above 160C, major exothermic decomposition can be observed with extrapolated onset temperatures of between 222C and 226C and peak temperatures between 235C and 238C. The test material was stable to sunlight but was not stable in the presence of metal at 50C for one week.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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