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EC number: 215-193-9 | CAS number: 1312-43-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Interstitial pulmonary disorders in indium-processing workers.
- Author:
- Chonan T, Taguchi O, Omae K
- Year:
- 2 007
- Bibliographic source:
- Eur Respir J 29:317-324
Materials and methods
- Study type:
- cross sectional study
- Endpoint addressed:
- basic toxicokinetics
- Principles of method if other than guideline:
- Investigation of indium in serum (In-S) in workers of ITO processing plant where dusts of ITO, indium trioxide are inhaled
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diindium trioxide
- EC Number:
- 215-193-9
- EC Name:
- Diindium trioxide
- Cas Number:
- 1312-43-2
- Molecular formula:
- In2O3
- IUPAC Name:
- bicyclo[1.1.1]diindoxane
- Details on test material:
- - Name of test material (as cited in study report): indium trioxide
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- confirmed and informed consent free of coercion received
- Details on study design:
- STUDY POPULATION: workers of ITO processing plant where dusts of ITO, indium trioxide are inhaled
E: 78 (M) current workers (mean age: 34±10 years, seniority: 3.3years (1.2-17.2)
+ 27 (M) former workers (mean age: 33±6 years), seniority: 4.6years (0.8-16.2)
C: 38 (M) - Exposure assessment:
- measured
- Details on exposure:
- TYPE OF EXPOSURE: occupational
TYPE OF EXPOSURE MEASUREMENT: Area air sampling , Biomonitoring blood (serum) - Statistical methods:
- Dunnett's test: to compare differences in mean In-S
Results and discussion
- Results:
- -indium in serum: (µg/L) Geometric mean (range):
current workers: 7.8 (SD4.3)
former workers: 8.3 (SD4.4)
controls: 0.3 (SD 2.6)
-indium in air: Air (µg/m3) GM (range): (10-50) - Confounding factors:
- Considered confounders:
- Smoking: yes
- Other simultaneous exposures: Indium tin oxide - Strengths and weaknesses:
- no information
Any other information on results incl. tables
none
Applicant's summary and conclusion
- Conclusions:
- Indium in serum (In-S) was determined as biological exposure index. Geometric means (GSD) of In-S were 7.8 µg/L (SD 4.3) in the exposed workers ,8.3 µg/L (SD 4.4) in the former workers and 0.3 (2.6) in the non-exposed workers.
- Executive summary:
78 male indium exposed; 27 former indium exposed and 38 male non-exposed workers from an ITO processing plant were analysed in a cross-sectional study. Indium in serum (In-S) was determined as biological exposure index. Geometric means (GSD) of In-S were 7.8 µg/L (SD 4.3) in the exposed workers ,8.3 µg/L (SD 4.4) in the former workers and 0.3 (2.6) in the non-exposed workers.
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