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Diss Factsheets
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EC number: 206-596-0 | CAS number: 355-93-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Some experimental studies have been conducted to investigate the degradation of OFPMA in the environment.
OFPMA hydrolyses rapidly in water to octafluoropentanol and methacrylic acid. The half lives of the OFPMA were reported to be 2.7 days for pH 4, 4.1 days for pH 7, and 3.9 hours for pH 9 at 25°C, using second order kinetics according to the non-GLP OECD Guideline 111 study.
OFPMA is not readily biodegradable according to two GLP-compliant OECD Guideline 310 studies. The minimum degradation reported was 22% after 28 days. Compound analysis confirmed octafluoropentanol was a biodegradation product of OFPMA. It was assumed the remaining portion of the OFPMA biodegraded to methacrylic acid which would have be further mineralized to carbon dioxide. The compound analysis did not detect further mineralization of the octafluoropentanol during the 28-day study period.
The adsorption/desorption properties of OFPMA were predicted based on the measured log Kow value. The regression method of Güsten and Sabljic (1995) has predicted the log Koc value to be 2.60 (i.e., Koc = 394). According to ECHA (2017), substances with log Koc greater than 4 are generally regarded as highly adsorptive and likely to distribute to sediment and soil. As the predicted Log Koc is less than 4, it is unlikely that OFPMA will distribute to sediment and soil.
Reference:
ECHA (2017). Guidance on Information Requirements and Chemical Safety Assessment: Chapter R.11: PBT/vPvB assessment. Version 3.0, June 2017.
Güsten H, Sabljic A (1995). QSARS for Soil Sorption. In: EC. Overview of Structure-Activity Relationships for Environmental Endpoints: Part 1: General Outline and Procedures: Report of the EU-DG-XII Project QSAR for Prediction of Fate and Effects of Chemicals in the Environment. European Commission (EC), Belgium, Chapter III, p. 6-13, 25-27. EV5V-CT92-0211 - Part 1.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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