Registration Dossier
Registration Dossier
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EC number: 202-430-6 | CAS number: 95-54-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- 1. Very limited information on methodology and results reported. 2. Non-standard method for acute toxicity testing.
Data source
Reference
- Reference Type:
- publication
- Title:
- Dominant lethal mutagenicity study on hair dyes
- Author:
- Burnett C, Loehr R, Corbett J
- Year:
- 1 977
- Bibliographic source:
- Journal of Toxicology and Environmental Health 2, 657-662
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- o-phenylenediamine
- EC Number:
- 202-430-6
- EC Name:
- o-phenylenediamine
- Cas Number:
- 95-54-5
- Molecular formula:
- C6H8N2
- IUPAC Name:
- benzene-1,2-diamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Charles River CD
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 10% DMSO
- No. of animals per sex per dose:
- 5 per group
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 516 mg/kg bw
- 95% CL:
- 474 - 560
Applicant's summary and conclusion
- Conclusions:
- LD50 (rat): 516 mg/kg
- Executive summary:
The LD50 in the rat after ip injection was reported as 516 mg/kg.
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