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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
other: Published data
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Pure talc has the formula Mg3Si4O10(OH)2 and a chemical composition of 31.88% by weight (wt) magnesium oxide (MgO), therefore the health effects of Magnesium oxide also should be taken into account

Data source

Reference
Reference Type:
publication
Title:
MAGNESIUM OXIDE - National Library of Medicine HSDB Database
Author:
Stilborn HL et al
Year:
1989
Bibliographic source:
Nutr. Rep. Int. 40 (1): 123-8 (1989)

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: OECD Guideline 414 (Prenatal Developmental Toxicity Study)
Deviations:
not specified
GLP compliance:
not specified
Type of method:
in vivo

Test material

Constituent 1
Chemical structure
Reference substance name:
Magnesium oxide
EC Number:
215-171-9
EC Name:
Magnesium oxide
Cas Number:
1309-48-4
Molecular formula:
MgO
IUPAC Name:
Magnesium oxide
Test material form:
solid

Test animals

Species:
other: hen
Strain:
other: laying
Sex:
female

Administration / exposure

Route of administration:
oral: feed
Vehicle:
other: corn and soiabean meal
Details on exposure:
To study the effects of supplemental magnesium in diets of laying hens on egg production and egg quality parameters, magnesium oxide (38% Mg) was used
Analytical verification of doses or concentrations:
not specified
Doses / concentrationsopen allclose all
Remarks:
Doses / Concentrations:
125 mg/Kg Mg
Basis:
nominal in diet
Remarks:
Doses / Concentrations:
250 mg/Kg Mg
Basis:
nominal in diet
Remarks:
Doses / Concentrations:
500 mg/Kg Mg
Basis:
nominal in diet
Remarks:
Doses / Concentrations:
750 mg/Kg Mg
Basis:
nominal in diet
Remarks:
Doses / Concentrations:
1000 mg/Kg Mg
Basis:
nominal in diet
No. of animals per sex per dose:
5
Control animals:
yes

Results and discussion

Effect levels

Dose descriptor:
dose level: oral feed
Effect level:
>= 1 000 mg/kg diet
Based on:
dissolved
Remarks:
magnesium
Sex:
female
Basis for effect level:
clinical signs

Observed effects

Results showed that layer performance including rate of egg production, egg wt, Haugh units, yolk color, shell break force, feed conversion, and body weight gain, was not influenced by the levels of supplemental Mg used.

Applicant's summary and conclusion

Conclusions:
Results showed that layer performance including rate of egg production, egg wt, Haugh units, yolk color, shell break force, feed conversion, and body weight gain, was not influenced by the levels of supplemental Mg used.
Executive summary:

To study the effects of supplemental magnesium in diets of laying hens on egg production and egg quality parameters, magnesium oxide (38% Mg) was used to provide 0, 125, 250, 500, 750 and 1,000 mg/kg supplemental Mg to the rations based upon corn and soybean meal. Each diet was fed to 5 replicates of 5 individually caged hens, following a forced molt. Results showed that layer performance including rate of egg production, egg wt, Haugh units, yolk color, shell break force, feed conversion, and body weight gain, was not influenced by the levels of supplemental Mg used.