Registration Dossier
Registration Dossier
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EC number: 238-877-9 | CAS number: 14807-96-6
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption, other
- Remarks:
- (Q)SAR calculated endpoint
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction:US EPA accepted QSAR method for chemicals properties assessment.
Data source
Reference
- Reference Type:
- other: QSAR model
- Title:
- EPI Suite v 4.1/ECOSARv1.00
- Author:
- US EPA
- Year:
- 2 014
- Bibliographic source:
- http://epa.gov/oppt/exposure/pubs/episuite.htm
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Using the DERMWIN v2.01 QSAR model
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
Test material
- Reference substance name:
- Talc (Mg3H2(SiO3)4)
- EC Number:
- 238-877-9
- EC Name:
- Talc (Mg3H2(SiO3)4)
- Cas Number:
- 14807-96-6
- Molecular formula:
- H2Mg3O12Si4
- IUPAC Name:
- Talc (Mg3H2(SiO3)4)
- Test material form:
- solid
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: QSAR model,
- Strain:
- other: QSAR model,
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- other: QSAR model
- Vehicle:
- other: QSAR model
- Duration of exposure:
- not applicable to QSAR models
- Doses:
- not applicable to QSAR models
- No. of animals per group:
- not applicable to QSAR models
- Control animals:
- no
- Details on study design:
- not applicable to QSAR models
- Details on in vitro test system (if applicable):
- not applicable to QSAR models
Results and discussion
- Signs and symptoms of toxicity:
- not specified
- Dermal irritation:
- not specified
- Absorption in different matrices:
- A QSAR model predicts that the permeability of Talc (Mg3H2(SiO3)4) to human skin is quite low. The permeability coefficient was determined to be 5.24e-008 mg/cm2, which is around 0.1% of the skin penetration rate.
Predicted dermally absorbed coefficient was determined to be Kp (est)= 6.58e-012 cm/hr.
Any other information on results incl. tables
A QSAR model predicts that the permeability of Talc (Mg3H2(SiO3)4) to human skin is quite low. The permeability coefficient was determined to be 5.24e-008 mg/cm2, which is around 0.1% of the skin penetration rate. Predicted dermally absorbed coefficient was determined to be Kp (est)= 6.58e-012 cm/hr.
Applicant's summary and conclusion
- Conclusions:
- A QSAR model predicts that the permeability of Talc (Mg3H2(SiO3)4) to human skin is quite low. The permeability coefficient was determined to be 5.24e-008 mg/cm2, which is around 0.1% of the skin penetration rate.
Predicted dermally absorbed coefficient was determined to be Kp (est)= 6.58e-012 cm/hr. - Executive summary:
A QSAR model predicts that the permeability of Talc (Mg3H2(SiO3)4) to human skin is quite low. The permeability coefficient was determined to be 5.24e-008 mg/cm2, which is around 0.1% of the skin penetration rate.
Predicted dermally absorbed coefficient was determined to be Kp (est)= 6.58e-012 cm/hr.
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