Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
0.019 mg/L
Assessment factor:
100
Extrapolation method:
assessment factor
PNEC freshwater (intermittent releases):
0.019 mg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.002 mg/L
Assessment factor:
1 000
Extrapolation method:
assessment factor

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
0.153 mg/L
Assessment factor:
100
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
29.217 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
29.217 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:
PNEC air

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
13.62 mg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Classification is triggered based on available data, according to REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006.

Conclusion on classification

Classification of tert-butyl-4-methoxyphenol for effects in the environment

Several major guideline – estimation values (Klimisch 2) are available for tert-butyl-4-methoxyphenol, which indicates considerable toxic effect in the three key trophic levels (fish, invertebrates and algae) when exposed to the substance, tert-butyl-4-methoxyphenol at concentrations up to its limit of solubility in the respective test media. Among the values lower values which lead to the classification of the substance the value which have been considered for further calculation (algae) is EC50 = 1.9 mg/L.

 

In determining the classification appropriate to tert-butyl-4-methoxyphenol, it is necessary to consider all available evidence concerning its persistence, potential to accumulate and predicted or observed environmental fate and behaviour that may present a long-term and/or delayed danger to the structure and/or functioning of aquatic ecosystems. These points are considered below.

 

Persistence

Reliable studies are available to demonstrate that tert-butyl-4-methoxyphenol is non persistent in nature and so is considered to be biodegradable in the environment. In other words tert-butyl-4-methoxyphenol may therefore be expected to degrade rapidly. Thus it can be inferred that tert-butyl-4-methoxyphenol is non persistent in environment. 

 

Potential to accumulate

Predicted and measured log Kow values for tert-butyl-4-methoxyphenol are less than 4 (Log Kow = 1). The potential for tert-butyl-4-methoxyphenol to bioaccumulate in the tissues of organisms that inhabit aquatic or terrestrial matrices is negligible as the BCF factor for the substance is less than 1000.  

 

Thus, tert-butyl-4-methoxyphenol is non persistent and does not satisfy the criteria for classification as persistent (P). 

 

The calculated BCF of cinnamaldehyde is 57.07 dimensionless and below the threshold of 2000. 

 

So,tert-butyl-4-methoxyphenol does not satisfy the criterion for classification as bioaccumulative (B).

 

The toxicity values of fish, invertebrates and algae are LC50 = 2.5 mg/L, EC50 = 2.3 mg/L are EC50 = 1.9 mg/L, respectively. All the values of the 3 trophic levels fall in the criteria for classification (as per CLP regulation in category 2) and so will not qualify for classification as per the CLP regulation in the above mentioned criteria.

Tert-butyl-4-methoxyphenol does satisfy the environmental effects criterion for classification as toxic (T).

 

Tert-butyl-4-methoxyphenol is not P & B (or vPvB) substance, but will qualify as T.