Registration Dossier

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Basic data given. The justification for the Read Across approach has been attached to the Section 13

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
AN ALTERNATIVES ASSESSMENT FOR THE FLAME RETARDANT DECABROMODIPHENYL ETHER (DecaBDE)
Author:
EPA United Stated Environmental Protection Agency
Year:
1994
Bibliographic source:
Not applicable
Reference Type:
secondary source
Title:
Not Available
Author:
Great Lakes ChemicalCorporation
Year:
1987
Bibliographic source:
Unpublished report

Materials and methods

Principles of method if other than guideline:
No available information on method used
GLP compliance:
not specified
Test type:
other: No available information

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No available information

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
No available information
Remarks on duration:
No available information
Concentrations:
No available information
No. of animals per sex per dose:
No available information
Control animals:
not specified
Details on study design:
No available information
Statistics:
No available information

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 87 000 mg/m³ air
Based on:
not specified
Remarks on result:
other: No information on exposition and confidence level
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 87 mg/L air
Based on:
not specified
Remarks on result:
other: No information on exposition and confidence level
Mortality:
No available information
Clinical signs:
other: No available information
Body weight:
No available information
Gross pathology:
No available information
Other findings:
No available information

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information According to the CLP Regulation Criteria used for interpretation of results: EU
Conclusions:
LC50 > 87000 mg/m3
Executive summary:

Method

The evaluation of acute inhalation toxicity reported from Greate Lakes Chemical Corporation (1982) in the WHO publication[1] has been considered in order to complete the assessment.

The test has been conducted on mouse. No further information on the method used is available.

Results

The LC50 by the inhalation route reported on the Similar Substance 01 in these reviews is greater than 87000 mg/m3 (LC50 > 87 mg/l).

 

 [1]World Health Organization (WHO, Geneva, 1995); Dr. G.J. van Esch “Tetrabromobisphenol A and Derivatived” (Environmental health criteria; 172)