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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Dissociation constant

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
dissociation constant
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
no guideline followed
Principles of method if other than guideline:
Calculation of pKa for anilines = 4.58 – 2.88∑sigma, sigmameta for NH2 = 0
GLP compliance:
not specified
Dissociating properties:
not determined
No.:
#2
pKa:
4.58
Temp.:
20 °C
Remarks on result:
other: pKa for anilines = 4.58 – 2.88∑sigma, sigmameta for NH2 = 0, room temperature assumed
Conclusions:
pKa: 4.58 at 20°C
Executive summary:

The pKa of the test substance was determined to be 4.58 at 20°C.

Description of key information

Calculated

Key value for chemical safety assessment

pKa at 20°C:
4.58

Additional information