Registration Dossier
Registration Dossier
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EC number: 204-399-4 | CAS number: 120-47-8
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC = 20 mg/L (result from ready biodegradability test according to OECD 301 F)
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 20 mg/L
Additional information
In accordance with Regulation (EC) 1907/2006, Column 2 of Annex VIII, section 9.1.4, studies on the inhibition of microbial respiration do not have to be conducted, as the substance is readily biodegradable and the applied test substance concentration of 20 mg/L is higher than the range of concentrations that can be expected in the influent of a sewage treatment plant.
For further assessment a ready biodegradability study is used to derive a NOEC for the toxicity to aquatic microorganisms. If a compound degrades well in a ready biodegradability test, or does not inhibit the degradation of a positive control at a certain concentration, this concentration can be used as a NOEC value. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2008). The substance was applied at a concentration of 20 mg/L in a ready biodegradability test according to OECD guideline 301 F. Within 28 days, the substance attained 88.4% degradation based on O2 consumption. Therefore, the NOEC for toxicity to aquatic microorganisms is stated as ≥ 20 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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