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Diss Factsheets
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EC number: 228-085-1 | CAS number: 6117-80-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- But-2-ene-1,4-diol
- EC Number:
- 203-787-0
- EC Name:
- But-2-ene-1,4-diol
- Cas Number:
- 110-64-5
- Molecular formula:
- C4H8O2
- IUPAC Name:
- 2-Butene-1,4-diol
- Reference substance name:
- (Z)-2-butene-1,4-diol
- EC Number:
- 228-085-1
- EC Name:
- (Z)-2-butene-1,4-diol
- Cas Number:
- 6117-80-2
- Molecular formula:
- C4H8O2
- IUPAC Name:
- but-2-ene-1,4-diol
- Details on test material:
- - Analytical purity: 99.5 %
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River GmbH WIGA , Sulzfeld
- Weight at study initiation: 26 g (mean)
- Housing: 5 animals per cage
- Diet (e.g. ad libitum): Kliba Haltungsdiaet; Klingenmuehle AG
- Water (e.g. ad libitum): tap water
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- - Vehicle used: water
- Duration of treatment / exposure:
- single oral administration
- Frequency of treatment:
- once
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100, 200, 400 mg/kg in 10 ml/kg distilled water
Basis:
analytical conc.
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Positive control(s):
- - Doses / concentrations: 20 mg/kg bw cyclophosphamide
- Doses / concentrations: 0.15 mg/Kg bw vincristine
Examinations
- Tissues and cell types examined:
- Bone marrow
- Statistics:
- Statistical evaluation was performed using the program system MUKERN (BASF AG).
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Any other information on results incl. tables
According to the results of the present study, the single oral administration of 2-Butene-1,4-diol did not lead to any increase in the number of polychromatic erythrocytes containing either small or large micronuclei.
No inhibition of erythropoiesis determined from the ratio of polychromatic to normochromatic erythrocytes was detected.
Under the experimental conditions chosen here, the test substance does not have any chromosome-damaging (clasto- genic) effect, and there were no indications of any impairment of chromosome distribution in the course of mitosis.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
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